CAJ | 학술논문

目的　探讨重症肌无力胸腺切除术后影响远期生存的因素。方法　采用胸腺切除术治疗170例重症肌无力患者，其中124例术后获得超过40个月的远期随访，运用COX回归模型分析可能影响远期预后生存的有关因素，包括胸腺的各病理类型、性别、年龄、病程、术前临床Osserman分型和治疗。结果　本项研究表明，胸腺的不同病理类型是影响胸腺切除术后远期生存的唯一重要因素，术后远期生存率有明显差异，表现为胸腺增生>良性胸腺瘤>胸腺萎缩>恶性胸腺瘤（P<0.05）。结论　胸腺的不同病理类型是影响重症肌无力胸腺切除术远期生存的重要因素。
목적　탐토중증기무력흉선절제술후영향원기생존적인소。 방법　채용흉선절제술치료170례중증기무력환자，기중124례술후획득초과40개월적원기수방，운용COX회귀모형분석가능영향원기예후생존적유관인소，포괄흉선적각병리류형、성별、년령、병정、술전림상Osserman분형화치료。 결과　본항연구표명，흉선적불동병리류형시영향흉선절제술후원기생존적유일중요인소，술후원기생존솔유명현차이，표현위흉선증생>량성흉선류>흉선위축>악성흉선류（P<0.05）。 결론　흉선적불동병리류형시영향중증기무력흉선절제술원기생존적중요인소。
Objective To study the factors affecting the long-term prognosis of patients with myasthenia gravis (MG) after thymectomy.Methods 170 MG patients who had undergone thymectomies were studied retrospectively. Among them, 124 patients received long-term follow-up for more than 40 months postoperatively. The COX regression analysis model was used to analyze the factors that may influence the long-term prognosis. These factors included thymus pathology, patient gender, age, duration of disease at the time of surgery, preoperative Osserman classification and medication.Results The research showed that thymus pathology was the single independent factor that affected the postoperative long-term prognosis. The long-term survival rates differed significantly with thymus pathological types: hyperplasia > benign thymoma > atrophy > malignant thymoma (P<0.05).Conclusion The different pathological types of the thymus were the important factor affecting long-term survival in MG patients after thymectomy.