中国中药杂志
中國中藥雜誌
중국중약잡지
CHINA JOURNAL OF CHINESE MATERIA MEDICA
2001年
6期
388-391
,共4页
大黄和虎杖炮制品%超氧阴离子%羟自由基%脂质过氧化
大黃和虎杖砲製品%超氧陰離子%羥自由基%脂質過氧化
대황화호장포제품%초양음리자%간자유기%지질과양화
目的:研究炮制对大黄、虎杖抗氧化作用的影响。方法:采用体外氧自由基生成系统和羟自由基诱导的小鼠肝匀浆脂质过氧化反应,评价炮制对大黄、虎杖抗氧化作用的影响。结果:大黄、虎杖炮制品均可清除次黄嘌呤-黄嘌呤氧化酶系统所产生超氧阴离子(O2*)以及Fenton反应生成的羟自由基(*OH),并能抑制羟自由基诱导的小鼠肝脏匀浆脂质过氧化,各炮制品EC50之间有一定显著性差异。结论:炮制降低大黄、虎杖抗氧化能力。
目的:研究砲製對大黃、虎杖抗氧化作用的影響。方法:採用體外氧自由基生成繫統和羥自由基誘導的小鼠肝勻漿脂質過氧化反應,評價砲製對大黃、虎杖抗氧化作用的影響。結果:大黃、虎杖砲製品均可清除次黃嘌呤-黃嘌呤氧化酶繫統所產生超氧陰離子(O2*)以及Fenton反應生成的羥自由基(*OH),併能抑製羥自由基誘導的小鼠肝髒勻漿脂質過氧化,各砲製品EC50之間有一定顯著性差異。結論:砲製降低大黃、虎杖抗氧化能力。
목적:연구포제대대황、호장항양화작용적영향。방법:채용체외양자유기생성계통화간자유기유도적소서간균장지질과양화반응,평개포제대대황、호장항양화작용적영향。결과:대황、호장포제품균가청제차황표령-황표령양화매계통소산생초양음리자(O2*)이급Fenton반응생성적간자유기(*OH),병능억제간자유기유도적소서간장균장지질과양화,각포제품EC50지간유일정현저성차이。결론:포제강저대황、호장항양화능력。
Objective:To investigate the effects of Processing on antioxidation of Radix et Rhizoma Rhei and Rhizoma Polygoni Cuspidati. Method: The oxygen free radicals generation system and mouse liver homogenate lipid peroxidation in vitro were used. Result:The processed products of Radix et Rhizoma Rhei and Rhizoma Polygoni Cuspidati could scavenge superoxide radical (O2*)generated through hypoxanthine-oxidase system and (*OH) generated through Fenton action, and inhibit lipid peroxidation induced by hydroxyl radical generation system, respectively. There existed significant differences among the different processed products. Conclusion:After Radix et Rhizoma Rhei and Rhizoma Polygoni Cuspidati were processed, their effects became weaker.