CAJ | 학술논문

目的观察心泰平对多种实验性心律失常的拮抗作用以及对大鼠血流动力学和心电图(ECG)的影响。方法采用乌头碱、BaCl2、电刺激和冠脉结扎诱发大鼠及家兔心律失常的4种实验动物模型，观察心泰平口服给药对心律失常的防治作用；大鼠左心室内插管，多道生理记录仪检测血流动力学指标和ECG。结果心泰平生药4g/kg与8g/kg明显延迟大鼠乌头碱性心律失常的出现时间(P<0.01)，降低室颤发生率，提高窦性节律恢复率，并显著提高家兔电刺激的室颤阈(P<0.01)，对大鼠BaCl2和冠脉结扎性心律失常也有一定的对抗作用；生药8g/kg可降低大鼠左室收缩压(LVSP)和-dp/dtmax(P<0.05)，延长Q-T间期(P<0.05)，无负性频率和传导作用。结论心泰平可防治多种心律失常，尤以功能性为佳，且对心脏抑制作用小。
목적 관찰심태평대다충실험성심률실상적길항작용이급대대서혈류동역학화심전도(ECG)적영향。방법 채용오두감、BaCl2、전자격화관맥결찰유발대서급가토심률실상적4충실험동물모형，관찰심태평구복급약대심률실상적방치작용；대서좌심실내삽관，다도생리기록의검측혈류동역학지표화ECG。결과 심태평생약4g/kg여8g/kg명현연지대서오두감성심률실상적출현시간(P<0.01)，강저실전발생솔，제고두성절률회복솔，병현저제고가토전자격적실전역(P<0.01)，대대서BaCl2화관맥결찰성심률실상야유일정적대항작용；생약8g/kg가강저대서좌실수축압(LVSP)화-dp/dtmax(P<0.05)，연장Q-T간기(P<0.05)，무부성빈솔화전도작용。결론 심태평가방치다충심률실상，우이공능성위가，차대심장억제작용소。
Objective To study the effects of Xintaiping(XTP) on experimentalarrhythmias,hemodynamics and ECG.Methods Using the animal arrhythmic models induced by aconitine,BaCl2,electric stimulation and coronary artery ligation,hemodynamics and ECG were assessed by means of left ventricular catheterization using a polygraph system in rats.Results XTP 4g/kg and 8g/kg prolonged significantly the onset time of aconitineinduced arrhythmias in rats(P<0.01),decreased the incidence of VF,and increased the threshold of electric stimulation-induced VF in rabbits (P<0.01).XTP could also counteract arrhythmias induced by BaCl2 and coronary occlusion in rats.XTP 8g/kg decreased LVSP and -dp/dtmax in rats(P<0.05),prolonged Q-T interval(P<0.05),but didn't affect dp/dtmax,SAP,heart beat and A-V.Conclusion XTP is a traditional Chinese herb with little heart inhibition,protectes the animals well from experimental arrhythmias,especially induced by aconitine and electric stimulation.