CAJ | 학술논문

目的　探讨高压氧治疗常年性变应性鼻炎的疗效及机理。方法　大、小鼠在压力为0.25 MPa的高压氧舱内,每日2 h,连续5或10 d,进行免疫指标测定。30例常年性变应性鼻炎患者,在0.2 MPa压力下的高压氧舱内吸纯氧,每日2 h,连续20 d,进行疗效评定。结果　吸高压氧后大鼠同种被动皮肤过敏反应受抑制(P<0.01)；小鼠耳异种被动皮肤过敏反应受抑制(P<0.01)；酪蛋白引起脱颗粒的小鼠腹腔肥大细胞数与对照组比较明显减少(P<0.01)。30例患者治疗前后症状、体征比较,近期疗效99%,随访3年有效率达74%。结论　高压氧对实验动物I型变态反应有显著抑制作用,对常年性变应性鼻炎是一种效果好、疗效稳定、无副作用的新治疗方法。
목적　탐토고압양치료상년성변응성비염적료효급궤리。방법　대、소서재압력위0.25 MPa적고압양창내,매일2 h,련속5혹10 d,진행면역지표측정。30례상년성변응성비염환자,재0.2 MPa압력하적고압양창내흡순양,매일2 h,련속20 d,진행료효평정。결과　흡고압양후대서동충피동피부과민반응수억제(P<0.01)；소서이이충피동피부과민반응수억제(P<0.01)；락단백인기탈과립적소서복강비대세포수여대조조비교명현감소(P<0.01)。30례환자치료전후증상、체정비교,근기료효99%,수방3년유효솔체74%。결론　고압양대실험동물I형변태반응유현저억제작용,대상년성변응성비염시일충효과호、료효은정、무부작용적신치료방법。
Objective　To explore the curative effect and mechanism of hyperbaric oxygenation(HBO) therapy for perennial allergic rhinitis.Methods　The immune indexes of rat and mouse were measured after 5 or 10 days under pressure of 0.25 MPa in HBO chamber for 2 hrs daily.At the same time,the curative effects of 30 cases suffered from perennial allergic rhinitis were evaluated after 20 days under HBO chamber with 0.2 MPa to inhale pure oxygen for 2 hrs/per day.Results　After HBO treatment,it was found that the passive skin allergic reaction in homozygous rats and heterologous mice(ears for test) all suppressed(P＜0.01)compared with the control group,the number of mase cells degranulated by casein in abdominal cavity of mice was markedly decreased(P＜0.01).On clinical observation,the near effects concerning symptoms and signs in 30 cases after HBO were 98.7%;follow-up 3 years,the effect was 73.7%.Conclusion　The study shows that the HBO has marked suppressive effect for allergic reaction of experimental animals,so,it is an effective,new and non-side-effect therapy for perennial allergic rhinits.