CAJ | 학술논문

对五种土霉素注射液产品（A、B、C、D和得米先20％）进行了猪体内的药代动力学比较研究。五组猪分别按20mg／kg的剂量耳后肌肉注射，HPLC测定血药浓度，3P97软件拟合血药浓度一时间数据，计算药代动力学参数。五种长效土霉素注射液均符合二室开放模型，峰浓度值分别为1．51、1．77、2．13、2．02、2．72Ixg／mL，AUC分别为48．45、60．22、52．41、66．04、59．8（μg·h）／mL。比较而言，得米先20％药动学最好，其次为产品C，产品B最差。
대오충토매소주사액산품（A、B、C、D화득미선20％）진행료저체내적약대동역학비교연구。오조저분별안20mg／kg적제량이후기육주사，HPLC측정혈약농도，3P97연건의합혈약농도일시간수거，계산약대동역학삼수。오충장효토매소주사액균부합이실개방모형，봉농도치분별위1．51、1．77、2．13、2．02、2．72Ixg／mL，AUC분별위48．45、60．22、52．41、66．04、59．8（μg·h）／mL。비교이언，득미선20％약동학최호，기차위산품C，산품B최차。
The pharmacokinetic properties of five oxytetrecycline injection（ A,B,C ,D and Terramycin LA 20% ） in clinically heathly pigs were campared and evaluated. Five groups of pig were given 20 mg/kg by muscular injection. Plasma concentration was determited by HPLC and concentration - time data was processed by 3P97. The results showed that the models of all groups were fit by two - comparment open model with peak plasma concentration of 1.51,1.77,2.13,2.02,2.72μg/mL and AUC of 8.45,60.22,52.41,66.04,59.8 （ μg·h）/mL. Terramycin LA 20% is the best in pharmacokinetics, then product C, and product B last.