中华肿瘤杂志
中華腫瘤雜誌
중화종류잡지
CHINESE JOURNAL OF ONCOLOGY
2011年
4期
291-294
,共4页
复方苦参注射液%肺癌%胃肠肿瘤%治疗
複方苦參註射液%肺癌%胃腸腫瘤%治療
복방고삼주사액%폐암%위장종류%치료
Compound Sophora flavescens Ait injection%Lung neoplasms%Gastrointestinal neoplasms%Therapy
目的 评价大剂量应用复方苦参注射液治疗中晚期恶性肿瘤的有效性和安全性.方法 采用非随机病例对照的研究方法,选取有明确病理诊断的中晚期肺癌和胃肠道肿瘤带瘤患者,依据治疗方案的不同,分为大剂量(20ml/d)应用苦参注射液的中药治疗组和化疗组各48例.结果 中药治疗组有47例患者、化疗组有46例患者完成治疗.中药治疗组患者的临床受益率为83.0%,明显高于化疗组(69.6%,P＜0.01).中药治疗组患者的Karnofsky评分提高率为57.4%,体重提高率为48.9%,均明显高于化疗组(30.4%和19.6%,P＜0.05).中药治疗组仅有1例患者出现轻度皮肤刺激反应,未发现其他与大剂量应用复方苦参注射液有关的临床不良反应.结论 对于中晚期恶性肿瘤患者大剂量应用复方苦参注射液安全、有效,推荐剂量为20ml/d.
目的 評價大劑量應用複方苦參註射液治療中晚期噁性腫瘤的有效性和安全性.方法 採用非隨機病例對照的研究方法,選取有明確病理診斷的中晚期肺癌和胃腸道腫瘤帶瘤患者,依據治療方案的不同,分為大劑量(20ml/d)應用苦參註射液的中藥治療組和化療組各48例.結果 中藥治療組有47例患者、化療組有46例患者完成治療.中藥治療組患者的臨床受益率為83.0%,明顯高于化療組(69.6%,P＜0.01).中藥治療組患者的Karnofsky評分提高率為57.4%,體重提高率為48.9%,均明顯高于化療組(30.4%和19.6%,P＜0.05).中藥治療組僅有1例患者齣現輕度皮膚刺激反應,未髮現其他與大劑量應用複方苦參註射液有關的臨床不良反應.結論 對于中晚期噁性腫瘤患者大劑量應用複方苦參註射液安全、有效,推薦劑量為20ml/d.
목적 평개대제량응용복방고삼주사액치료중만기악성종류적유효성화안전성.방법 채용비수궤병례대조적연구방법,선취유명학병리진단적중만기폐암화위장도종류대류환자,의거치료방안적불동,분위대제량(20ml/d)응용고삼주사액적중약치료조화화료조각48례.결과 중약치료조유47례환자、화료조유46례환자완성치료.중약치료조환자적림상수익솔위83.0%,명현고우화료조(69.6%,P＜0.01).중약치료조환자적Karnofsky평분제고솔위57.4%,체중제고솔위48.9%,균명현고우화료조(30.4%화19.6%,P＜0.05).중약치료조부유1례환자출현경도피부자격반응,미발현기타여대제량응용복방고삼주사액유관적림상불량반응.결론 대우중만기악성종류환자대제량응용복방고삼주사액안전、유효,추천제량위20ml/d.
Objective To evaluate the effectiveness and safety of large dose compound Sophora flavescens Ait injection in the treatment of advanced malignant tumors.Methods A non-randomized case control trial was conducted.Ninety six patients with pathologically confirmed advanced non-small-cell lung cancer, gastric cancer and colorectal cancer were divided into traditional Chinese medicine group and chemotherapy group, 48 cases each.Patients of the traditional Chinese medicine group received treatment with large dose of compound Sophora flavescens Ait injection (20 ml/d), and 21 days as a cycle.Results Fortyseven patients of the traditional Chinese medicine group and 46 patients of the chemotherapy group completed their treatment, respectively.The clinical benefit rate (CBR) in the traditional Chinese medicine group was 83.0%, significantly higher than that in the chemotherapy group (69.6%)(P＜0.01).The Kamofsky performance status and weight improvement in the traditional Chinese medicine group was superior to that in the chemotherapy group ( P ＜ 0.05 ).Except the skin irritation in one patient in the traditional Chinese medicine group, there were no other clinical adverse effects related with the large dose compound Sophora flavescens Ait injection.Conclusions Large dose compound Sophora flavescens Ait injection in the treatment of advanced malignant tumors is safe and effective.The recommended dose is 20 ml/d.
