CAJ | 학술논문

目的研究环氧合酶-2 (Cox-2)蛋白在食管癌及癌前病变组织中的表达，探讨非类固醇抗炎药在食管癌高危人群中化学预防的可能性。方法应用免疫组织化学方法检测120例食管癌(原位癌30例，鳞状细胞癌60例，腺癌30例)及其113例增生性病变(单纯增生29例，轻、中、重度不典型增生分别为31例、30例、23例)和27例正常食管黏膜鳞状上皮,以及3例Barrett食管组织中Cox-2蛋白的表达情况。结果在正常食管黏膜上皮，单纯增生，轻、中、重度不典型增生，原位癌未发现有Cox-2蛋白表达；在6%(4/60)侵袭性鳞状细胞癌和70%(21/30)的食管腺癌中，Cox-2蛋白表达阳性。结论 Cox-2蛋白表达可能与食管腺癌的形成有关,而与鳞状细胞癌的发生发展无关。
목적연구배양합매-2 (Cox-2)단백재식관암급암전병변조직중적표체，탐토비류고순항염약재식관암고위인군중화학예방적가능성。방법응용면역조직화학방법검측120례식관암(원위암30례，린상세포암60례，선암30례)급기113례증생성병변(단순증생29례，경、중、중도불전형증생분별위31례、30례、23례)화27례정상식관점막린상상피,이급3례Barrett식관조직중Cox-2단백적표체정황。결과재정상식관점막상피，단순증생，경、중、중도불전형증생，원위암미발현유Cox-2단백표체；재6%(4/60)침습성린상세포암화70%(21/30)적식관선암중，Cox-2단백표체양성。결론 Cox-2단백표체가능여식관선암적형성유관,이여린상세포암적발생발전무관。
Objective　To investigate cyclooxygenase-2(Cox-2) protein expression in esophageal cancer and precancerous lesions.　Methods　One hundred twenty biopsy specimens from patients with esophageal carcinoma，113 from patients with esophageal premalingnant lesions，27 from individuals with normal esophageal mucosa and 3 from Barrett's esophagus were examined for Cox-2 protein expression by immunohistochemistry.　 Results Cox-2 protein was not observed in normal esophageal squamous and glandular epithelium, hyperplasia from mild to severe dysplasia lesions and carcinoma in situ. Positive Cox-2 expression was found in 4 of 60 specimens of invasive squamous-cell carcinomas, 21 of 30 specimens of esophageal adenocarcinomas and in 3 of 3 Barrett′s esophageal tissues.　Conclusion　The Cox-2 protein expression may be associated with the development of the esophageal adenocarcinomas but not esophageal squamous-cell carcinomas.