CAJ | 학술논문

背景慢性、持续的疼痛可能是患者就医最常见的原因,因此,临床上对慢性疼痛的治疗日益重视.目的简要介绍碱性成纤维细胞生长因子(basic fibroblast growth factor,FGF-2)的生物学特性及功能,重点综述其与星形胶质细胞活化的关系及参与慢性疼痛调控的研究进展.内容星形胶质细胞在慢性疼痛的发生、发展过程中起着关键作用,FGF-2是星形胶质细胞的有效激活剂,慢性疼痛发生时FGF-2在活化的脊髓星形胶质细胞中增加.趋向FGF-2调控疼痛的信号转导通路有待进一步研究,疼痛过程是由多种细胞和因子共同调节,它们的相互作用机制有待于进一步探讨.
배경만성、지속적동통가능시환자취의최상견적원인,인차,림상상대만성동통적치료일익중시.목적간요개소감성성섬유세포생장인자(basic fibroblast growth factor,FGF-2)적생물학특성급공능,중점종술기여성형효질세포활화적관계급삼여만성동통조공적연구진전.내용성형효질세포재만성동통적발생、발전과정중기착관건작용,FGF-2시성형효질세포적유효격활제,만성동통발생시FGF-2재활화적척수성형효질세포중증가.추향FGF-2조공동통적신호전도통로유대진일보연구,동통과정시유다충세포화인자공동조절,타문적상호작용궤제유대우진일보탐토.
Background Chronic persistent pain is probably the most commonindicator for patients seeking therapy in clinics.The effective therapy for chronic persistent pain is emphasized much more than before.Objective To introduce the biological characteristics of basic fibroblast growth factor (FGF-2) and its functions in regulations of chronic pain.Content Astrocytes plays an important role in chronic pain.FGF-2 is a well-known activator of astrocytes,which increased in spinal cord during chronic pain.Trend How FGF-2 regulates the pain signal pathway needs to be further explored.The process of pain is composed of multiple cells and factors and their interaction mechanism needs further research.