国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
INTERNATIONAL JOURNAL OF PEDIATRICS
2010年
4期
399-402
,共4页
不对称二甲基精氨酸%早产,婴儿,疾病
不對稱二甲基精氨痠%早產,嬰兒,疾病
불대칭이갑기정안산%조산,영인,질병
ADMA%Preterm infant,disease
不对称二甲基精氨酸(ADMA)是一氧化氮合酶(NOS)的内源性竞争性抑制剂,是血管内皮功能不全的危险因子.近年来研究发现,ADMA不仅是预测急性心血管疾病的危险因子,而且是一种新的预测危重疾病及死亡的危险因子.在动物实验及体外实验发现,外源性ADMA能明显改变肺功能,诱导细胞凋亡.在缺氧、PPHN、需机械通气的早产儿、脑损伤中,ADMA水平均升高.ADMA可能是预测新生儿严重并发症和死亡的独立危险因子.
不對稱二甲基精氨痠(ADMA)是一氧化氮閤酶(NOS)的內源性競爭性抑製劑,是血管內皮功能不全的危險因子.近年來研究髮現,ADMA不僅是預測急性心血管疾病的危險因子,而且是一種新的預測危重疾病及死亡的危險因子.在動物實驗及體外實驗髮現,外源性ADMA能明顯改變肺功能,誘導細胞凋亡.在缺氧、PPHN、需機械通氣的早產兒、腦損傷中,ADMA水平均升高.ADMA可能是預測新生兒嚴重併髮癥和死亡的獨立危險因子.
불대칭이갑기정안산(ADMA)시일양화담합매(NOS)적내원성경쟁성억제제,시혈관내피공능불전적위험인자.근년래연구발현,ADMA불부시예측급성심혈관질병적위험인자,이차시일충신적예측위중질병급사망적위험인자.재동물실험급체외실험발현,외원성ADMA능명현개변폐공능,유도세포조망.재결양、PPHN、수궤계통기적조산인、뇌손상중,ADMA수평균승고.ADMA가능시예측신생인엄중병발증화사망적독립위험인자.
Asymmetric dimethylarginine(ADMA) is an endogenous inhibitor of nitric oxide synthases(NOS),which is a risk marker of cardiovascular endothelial dysfunction.Recent studies found that ADMA was a predictor not only for acute cardiovascular disease,but also for critical illness and mortality.Studies have found that exogenous ADMA altered lung function and induced apoptosis in animal experiments and vitro experiments.The levels of plasma ADMA significantly increased in children with hypoxia,PPHN,brain damage,and preterm infants who required mechanical ventilation.ADMA could be a independent risk factor to predict neonatal complications and death.
