CAJ | 학술논문

目的探讨血清可溶性细胞间粘附分子-1(sICAM-1)在肾移植术后免疫学监测中的价值.方法采用酶联免疫吸附法(ELISA)动态监测56例肾移植患者术后血清sICAM-1的变化.结果肾移植患者术后发生排斥反应时,其sICAM-1水平(390.6 μ/L±91.0 μg/L)明显高于移植肾功能稳定者(137.3μg/L±16.8 μg/L)和环孢素A(CsA)肾中毒者(132.7 μg/L±24.8 μg/L),差异有极显著性(P＜0.01);抗排斥反应治疗有效后,sICAM-1逐渐降至正常水平;CsA肾中毒者的sICAM-1水平无明显变化.结论肾移植术后动态监测患者血清sICAM-1水平的变化,有助于急性排斥反应的诊断、鉴别诊断及抗排斥治疗的疗效评价,可以作为肾移植术后急性排斥反应的免疫学监测指标.
목적 탐토혈청가용성세포간점부분자-1(sICAM-1)재신이식술후면역학감측중적개치.방법 채용매련면역흡부법(ELISA)동태감측56례신이식환자술후혈청sICAM-1적변화.결과 신이식환자술후발생배척반응시,기sICAM-1수평(390.6 μ/L±91.0 μg/L)명현고우이식신공능은정자(137.3μg/L±16.8 μg/L)화배포소A(CsA)신중독자(132.7 μg/L±24.8 μg/L),차이유겁현저성(P＜0.01);항배척반응치료유효후,sICAM-1축점강지정상수평;CsA신중독자적sICAM-1수평무명현변화.결론 신이식술후동태감측환자혈청sICAM-1수평적변화,유조우급성배척반응적진단、감별진단급항배척치료적료효평개,가이작위신이식술후급성배척반응적면역학감측지표.
Objective To evaluate the values of serum soluble intercellular adhesion molecule-1 (sICAM-1)in monitoring acute rejection after renal transplantation.Method The levels of serum sICAM-1 was sequentially monitored by means of ELISA in 56 renal transplantation recipients including 19 with acute rejection and 6 with cyclosporine nephrotoxicity.Results The level of sICAM-1 during acute rejection was significantly higher than those with stable allograft function or with cyclosporine nephrotoxicity(P＜0.01).After antirejection therapy Was successfully given,the level of sICAM-1 came down to the normal level.Conclusions Sequential monitoring of seruIn sICAM-1 is helpful for the diagnosis and differential diagnosis of acute reiection as well as the evaluation of the acute rejection therapeutic effects.Serum sICAM-1 can be used as a potent marker in monitoring acute rejection after renal transplantation.