CAJ | 학술논문

目的研究肝豆状核变性(即Wilson病,WD)患者脑局部葡萄糖代谢变化特征.方法对13例伴有神经系统症状的WD患者和12名健康对照者进行脑18F-脱氧葡萄糖(FDG)PET静态显像,采用视觉分析、半定量分析和统计参数图(SPM)分析方法判断FDG PET显像结果.采用SPSS11.0软件进行统计学处理,将WD患者组与健康对照组进行组间统计分析.结果 WD患者FDGPET脑静态显像示双侧豆状核和尾状核放射性摄取较对照组对称性减低,前者比后者更明显;大脑皮质、丘脑、小脑放射性分布基本均匀、对称.WD患者豆状核和尾状核与大脑皮质放射性比值(0.95±0.05和1.02±0.06)明显低于对照组(1.26±0.05和1.17±0.05,t=15和8,P均<0.05),WD组豆状核与尾状核的放射性比值(0.93±0.06)明显低于对照组(1.09±0.06,t=9,P<0.05),丘脑和小脑与大脑皮质放射性比值与对照组差异无统计学意义(WD组:0.99±0.06和0.98±0.06,对照组:1.00±0.05和0.99±0.05;t=0.7和0.8,P均>0.05).结论 WD患者FDG PET脑静态显像特征为双侧豆状核和尾状核放射性摄取对称性减低,豆状核放射性摄取减低程度比尾状核更明显,FDG PET脑静态显像对鉴别诊断表现为神经系统异常的WD患者有价值.
목적 연구간두상핵변성(즉Wilson병,WD)환자뇌국부포도당대사변화특정.방법 대13례반유신경계통증상적WD환자화12명건강대조자진행뇌18F-탈양포도당(FDG)PET정태현상,채용시각분석、반정량분석화통계삼수도(SPM)분석방법판단FDG PET현상결과.채용SPSS11.0연건진행통계학처리,장WD환자조여건강대조조진행조간통계분석.결과 WD환자FDGPET뇌정태현상시쌍측두상핵화미상핵방사성섭취교대조조대칭성감저,전자비후자경명현;대뇌피질、구뇌、소뇌방사성분포기본균균、대칭.WD환자두상핵화미상핵여대뇌피질방사성비치(0.95±0.05화1.02±0.06)명현저우대조조(1.26±0.05화1.17±0.05,t=15화8,P균<0.05),WD조두상핵여미상핵적방사성비치(0.93±0.06)명현저우대조조(1.09±0.06,t=9,P<0.05),구뇌화소뇌여대뇌피질방사성비치여대조조차이무통계학의의(WD조:0.99±0.06화0.98±0.06,대조조:1.00±0.05화0.99±0.05;t=0.7화0.8,P균>0.05).결론 WD환자FDG PET뇌정태현상특정위쌍측두상핵화미상핵방사성섭취대칭성감저,두상핵방사성섭취감저정도비미상핵경명현,FDG PET뇌정태현상대감별진단표현위신경계통이상적WD환자유개치.
Objective The aim of this study was to investigate the characteristic of regional cerebral glucose metabolism in patients with Wilson's disease (WD) using 18F-fluorodeoxyglucose (FDG) PET.Methods Thirteen WD patients and 12 normal controls were studied by brain 18F-FDG PET, and the data were analyzed by visual analysis, semi-quantification and statistical parametric mapping (SPM). The radioactivity ratios of lenticular nuclei, caudate, thalamus and cerebellum to cerebral cortex and the ratio of lenticular nuclei to caudate were calculated, respectively. SPSS 11.0 software for statistics was also used to analyze the data. Results In WD patients, radioactivity of lenticular nuclei and candate was significantly decreased compared with controls. The radioactivity ratios of lenticular nuclei and caudate to cerebral cortex in WD patients were both significantly lower than that in normal controls (0.95±0.05 vs 1.26±0.05, t =15, P < 0.05 ; 1.02±0.06 vs 1.17±0.05, t = 8, P < 0.05), and the ratio of lenticular nuclei to caudate in WD patients was significantly higher than that in normal controls (0.93±0.06 vs 1.09±0.06, t =9, P< 0.05). Conclusion As compared with normal controls, patients with WD had significantly decreased glucose utilization in the basal ganglia, especially in the lenticullar nuclei.