中华传染病杂志
中華傳染病雜誌
중화전염병잡지
CHINESE JOURNAL OF INFECTIOUS DISEASES
2010年
11期
667-671
,共5页
吕锡宏%杨忠东%陈浩%蒋懿%居丽雯%朱渭萍%周艳冰%申惠国%蒋露芳%施强%姜庆五
呂錫宏%楊忠東%陳浩%蔣懿%居麗雯%硃渭萍%週豔冰%申惠國%蔣露芳%施彊%薑慶五
려석굉%양충동%진호%장의%거려문%주위평%주염빙%신혜국%장로방%시강%강경오
流感,人%流感病毒A型,H1N1亚型%流感病毒A型,H3N2亚型%抗体,病毒%血凝集抑制试验
流感,人%流感病毒A型,H1N1亞型%流感病毒A型,H3N2亞型%抗體,病毒%血凝集抑製試驗
류감,인%류감병독A형,H1N1아형%류감병독A형,H3N2아형%항체,병독%혈응집억제시험
Influenza,human%Influenza A virus,H1N1 subtype%Influenza A virus,H3N2 subtype%Antibodies,viral%Hemagglutinin inhibition tests
目的 了解上海地区人群季节性H1、H3亚型流感病毒抗体水平及职业人群中H5、H9亚型禽流感抗体的检出情况.方法 应用血凝抑制试验对上海地区2009年与禽类密切接触的职业人群356人以及一般人群332人各年龄组进行H1、H3、H5、H9亚型流感病毒抗体的血清学监测.结果 A/Brisbane/59/2007(H1N1)抗体阳性分布,一般人群有275人,占82.8%,职业人群有263人,占73.9%;A/Brisbane/10/2007(H3N2)抗体阳性,一般人群有168人,占50.6%,职业人群有195人,占54.8%;人群中A/Brisbane/59/2007(H1N1)抗体阳性率明显高于H3,与2008年上海地区流感病原学监测情况相吻合.职业人群与一般人群H5亚型抗体阳性率分别为4.2%(15/356)和0.3%(1/332);H9亚型抗体阳性率分别为34.6%(123/356)和2.4%(8/332).不同年龄组中,6个月～5岁年龄组和≥60岁的老年组A/Brisbane/59/2007(H1N1)、A/Brisbane/10/2007(H3N2)抗体阳性率较低.结论 上海地区人群对H1、H3季节性流感有较强的免疫保护,儿童和老年人群H1、H3季节性流感抗体水平较低.职业人群禽流感病毒H5、H9抗体有明显升高趋势,要加强对职业人群流感样患者病原学和血清流行病学监测.
目的 瞭解上海地區人群季節性H1、H3亞型流感病毒抗體水平及職業人群中H5、H9亞型禽流感抗體的檢齣情況.方法 應用血凝抑製試驗對上海地區2009年與禽類密切接觸的職業人群356人以及一般人群332人各年齡組進行H1、H3、H5、H9亞型流感病毒抗體的血清學鑑測.結果 A/Brisbane/59/2007(H1N1)抗體暘性分佈,一般人群有275人,佔82.8%,職業人群有263人,佔73.9%;A/Brisbane/10/2007(H3N2)抗體暘性,一般人群有168人,佔50.6%,職業人群有195人,佔54.8%;人群中A/Brisbane/59/2007(H1N1)抗體暘性率明顯高于H3,與2008年上海地區流感病原學鑑測情況相吻閤.職業人群與一般人群H5亞型抗體暘性率分彆為4.2%(15/356)和0.3%(1/332);H9亞型抗體暘性率分彆為34.6%(123/356)和2.4%(8/332).不同年齡組中,6箇月～5歲年齡組和≥60歲的老年組A/Brisbane/59/2007(H1N1)、A/Brisbane/10/2007(H3N2)抗體暘性率較低.結論 上海地區人群對H1、H3季節性流感有較彊的免疫保護,兒童和老年人群H1、H3季節性流感抗體水平較低.職業人群禽流感病毒H5、H9抗體有明顯升高趨勢,要加彊對職業人群流感樣患者病原學和血清流行病學鑑測.
목적 료해상해지구인군계절성H1、H3아형류감병독항체수평급직업인군중H5、H9아형금류감항체적검출정황.방법 응용혈응억제시험대상해지구2009년여금류밀절접촉적직업인군356인이급일반인군332인각년령조진행H1、H3、H5、H9아형류감병독항체적혈청학감측.결과 A/Brisbane/59/2007(H1N1)항체양성분포,일반인군유275인,점82.8%,직업인군유263인,점73.9%;A/Brisbane/10/2007(H3N2)항체양성,일반인군유168인,점50.6%,직업인군유195인,점54.8%;인군중A/Brisbane/59/2007(H1N1)항체양성솔명현고우H3,여2008년상해지구류감병원학감측정황상문합.직업인군여일반인군H5아형항체양성솔분별위4.2%(15/356)화0.3%(1/332);H9아형항체양성솔분별위34.6%(123/356)화2.4%(8/332).불동년령조중,6개월～5세년령조화≥60세적노년조A/Brisbane/59/2007(H1N1)、A/Brisbane/10/2007(H3N2)항체양성솔교저.결론 상해지구인군대H1、H3계절성류감유교강적면역보호,인동화노년인군H1、H3계절성류감항체수평교저.직업인군금류감병독H5、H9항체유명현승고추세,요가강대직업인군류감양환자병원학화혈청류행병학감측.
Objective To know the levels of antibodies against influenza A virus subtypes H1 and H3 of population in Shanghai during 2009, and the detection of antibodies against avian influenza virus subtypes H5 and H9 in population which contacts with avian. Methods The serological survey of the antibodies against influenza A viruses subtypes H1, H3, H5 and H9 in 356 close contacts with avian (professional population) and 332 general subjects (general population) at various age groups were carried out using hemagglutinin inhibit (HI) test. Results The positive rates of antibodies against influenza virus A/Brisbane/59/2007 (H1N1) in general population and professional population were 82.8% (275/332) and 73.9% (263/356), respectively; those of A/Brisbane/10/2007 (H3N2)were 50.6% (168/332) and 54.8% (195/356), respectively. The positive rate of antibodies against influenza virus A/Brisbane/59/2007 (H1N1 )was significantly higher than that of influenza A viruses subtype H3, which was consistent with etiological survey of influenza virus in Shanghai during 2008.The positive rates of antibodies against influenza A virus subtype H5 in professional population and general population were 4.2% (15/356) and 0.3% (1/332), respectively; those of influenza A virus subtype H9 were 34.6% (123/356) and 2.4% (8/332), respectively. The positive rates of antibodies against influenza virus A/Brisbane/59/2007 (H1N1 ) and A/Brisbane/10/2007 (H3N2) in age groups of 6 months-5 years and ≥60 years were lower than other age groups. Conclusions The immune protective response against seasonal influenza A subtype H1 and H3 of population in Shanghai is high,while those of children and the elders were low. The levels of antibodies against influenza A viruses subtype H5 and H9 in professinal population present obviously ascending trend, which indicates that the etiological and serological survey of influenza virus in this population should be enhanced.
