CAJ | 학술논문

近年来,非甾体类抗炎镇痛药(NSAIDs)越来越多地用于围术期镇痛以减少阿片类药的副作用.NSAIDs药物通过抑制环氧化酶而减少前列腺素的合成从而达到镇痛的目的 .此综述将从以下几个方面论述NSAIDs药物用于围术期镇痛:①短小手术后镇痛;②停用PCA以后镇痛;③辅助阿片类药物用于中等和大手术后镇痛;④抗炎效应;⑤超前镇痛.NSAIDs药物主要的副作用是胃肠道反应、出血以及目前关注较多的心血管问题,但短时间用于术后镇痛是很安全的.随着越来越多的选择性或特异性环氧化酶.2抑制剂的研制,NSAIDs药物将为病人带来更安全更有效的围术期多模式镇痛.
근년래,비치체류항염진통약(NSAIDs)월래월다지용우위술기진통이감소아편류약적부작용.NSAIDs약물통과억제배양화매이감소전렬선소적합성종이체도진통적목적 .차종술장종이하궤개방면논술NSAIDs약물용우위술기진통:①단소수술후진통;②정용PCA이후진통;③보조아편류약물용우중등화대수술후진통;④항염효응;⑤초전진통.NSAIDs약물주요적부작용시위장도반응、출혈이급목전관주교다적심혈관문제,단단시간용우술후진통시흔안전적.수착월래월다적선택성혹특이성배양화매.2억제제적연제,NSAIDs약물장위병인대래경안전경유효적위술기다모식진통.
More and more NSAIDs are used in the management of post-operative pain in order to reduce the side effects derived from opioids. NSAIDs exert analgesia by inhibiting cyclo-oxygenase enzymes and decreasing peripheral and central prostaglandin production. This review discusses the role of NSAIDs in perioperative analgesia on various clinical occasions.