CAJ | 학술논문

背景脑水肿和颅内压(intracranial pressure,ICP)增高的治疗一直是神经外科患者围手术期治疗的重要组成部分,也是决定患者预后的重要因素之一,甘露醇作为目前临床控制颅内高压的基本药物,其副作用及治疗局限性正被临床医生所重视.探讨更加有效的治疗方法已经成为目前国内外学者研究的热点.目的针对高渗盐水(hypertonic saline,HS)在各种神经外科疾病引起的脑水肿和ICP增高的治疗中的应用作一综述.内容主要阐述近年来HS防治脑水肿及ICP增高的相对明确的作用机制及其在各种神经外科疾病中的运用研究.趋向HS作为甘露醇的替代品,在脑水肿和ICP增高的治疗中正日益发挥着重要的作用.
배경뇌수종화로내압(intracranial pressure,ICP)증고적치료일직시신경외과환자위수술기치료적중요조성부분,야시결정환자예후적중요인소지일,감로순작위목전림상공제로내고압적기본약물,기부작용급치료국한성정피림상의생소중시.탐토경가유효적치료방법이경성위목전국내외학자연구적열점.목적침대고삼염수(hypertonic saline,HS)재각충신경외과질병인기적뇌수종화ICP증고적치료중적응용작일종술.내용주요천술근년래HS방치뇌수종급ICP증고적상대명학적작용궤제급기재각충신경외과질병중적운용연구.추향HS작위감로순적체대품,재뇌수종화ICP증고적치료중정일익발휘착중요적작용.
Background The treatment of cerebral edema and increased intracranial pressure (ICP) has long been a critical component of perioperative care in neurosurgical practice,which is also a vital determinant for the prognosis.Currently,mannitol is the most fundamental agent to control the ICP in clinical practice,and the side effects of the mannitol are increasingly reported.Intensive researches were performed to find a more effective and safe agent for cerebral edema and ICP.Objective The role of hypertonic saline(HS) in controlling increased ICP caused by various neurosurgical diseases will be clarified.Content The review mainly explicates the definite mechanism and related application of HS in neurosurgical diseases.Trend HS has emerged as an alternative to mannitol,and provides a new promising therapy for patients suffering cerebral edema and increased intracranial pressure.