CAJ | 학술논문

目的通过开展西藏疟疾流行区墨脱和察隅两县人群血清流行病学调查,评价当地疟疾流行程度.方法 2010-2011年在墨脱县的背崩、达木、甘登、朱村、墨脱村、地东和察隅的格拥、米古、西巴、嘎堆、塔玛、日玛、松古、扎巴、沙玛共15个居民点采集1520名不同年龄组人群(1～80岁)的滤纸血,用间接荧光抗体试验法检测疟疾抗体水平,计算抗体阳性率及阳性几何平均滴度倒数(geometric mean reciprocal titer,GMRT)；20岁以下年龄组人群抗体阳性率用可逆催化模型估算当地年感染概率,并与当年疟疾发病率进行比较；以抗体滴度≥1:80以上者估算带虫率.结果墨脱调查点平均疟疾抗体阳性率为3.51％(31/883),以此估算的年感染概率为0.51％,与当年疟疾发病率0.32％较为接近；察隅调查点平均抗体阳性率为5.51％(22/399),以此估算的年感染概率为1.24％,而当年疟疾发病率为0.两地不同年龄组人群抗体阳性率均随着年龄增长而升高.结论血清学调查抗体阳性率和以此估算的年感染概率基本能反映西藏疟疾流行区墨脱县和察隅县的疟疾流行程度,人群较高的抗体水平显示两地均存在地方性流行.
목적 통과개전서장학질류행구묵탈화찰우량현인군혈청류행병학조사,평개당지학질류행정도.방법 2010-2011년재묵탈현적배붕、체목、감등、주촌、묵탈촌、지동화찰우적격옹、미고、서파、알퇴、탑마、일마、송고、찰파、사마공15개거민점채집1520명불동년령조인군(1～80세)적려지혈,용간접형광항체시험법검측학질항체수평,계산항체양성솔급양성궤하평균적도도수(geometric mean reciprocal titer,GMRT)；20세이하년령조인군항체양성솔용가역최화모형고산당지년감염개솔,병여당년학질발병솔진행비교；이항체적도≥1:80이상자고산대충솔.결과 묵탈조사점평균학질항체양성솔위3.51％(31/883),이차고산적년감염개솔위0.51％,여당년학질발병솔0.32％교위접근；찰우조사점평균항체양성솔위5.51％(22/399),이차고산적년감염개솔위1.24％,이당년학질발병솔위0.량지불동년령조인군항체양성솔균수착년령증장이승고.결론 혈청학조사항체양성솔화이차고산적년감염개솔기본능반영서장학질류행구묵탈현화찰우현적학질류행정도,인군교고적항체수평현시량지균존재지방성류행.
Objective To evaluate malaria endemic situation by seroepidemiological investigation in Motuo County and Chayu County in Tibet.Methods 1520 blood filter papers were collected from 1-80 years old in 15 study sites at the Beibeng,Damu,Gandeng,Zhucun,Motuo town,Didong,Geyong,Migu,Xiba,Gadui,Tama,Rima,Songgu,Zhaba,Shama of Motuo County and Chayu County in 2010 and 2011.All the blood samples were tested by indirect haemagglutination test (IFAT) to calculate malaria antibody positive rate (APR) and positive geometric mean reciprocal titer (GMRT).The predictive infection probability was evaluated by reversible catalytic model based on antibody positive rate in the group of less than 20 year-old and compared to the annual parasite incidence,and the predictive parasitic rate was calculated by the number of sample malaria antibody titer over 1:80.Results The average APR in Motuo sites was 3.51％ (31/883),and the predictive infection probability was 0.51％,well matched to the annual malaria incidence (0.32％) ;The APR in Chayu sites was 5.51％ (22/399),and the predictive infection probability was 1.24％,while the annual malaria incidence was 0 in the same year.The APRs in different age groups were increased by age in these two counties.Conclusion The APR and the predictive infection probability based on seroepidemiological investigations can well evaluate malaria endemic situation in Tibet.Higher APR indicated the existence of malaria transmission there in recent years.Although no malaria cases were reported in the study period,higher APR and the predictive infection probability implied the existence of potential infectious resources of malaria there.