国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2011年
11期
1330-1333
,共4页
尿促性素%多囊卵巢综合征(PCOS)%不孕症%多胎妊娠
尿促性素%多囊卵巢綜閤徵(PCOS)%不孕癥%多胎妊娠
뇨촉성소%다낭란소종합정(PCOS)%불잉증%다태임신
HMG%Polycystic ovary syndrome%Infertility%Multiple pregnancy
目的 比较不同促排卵方案治疗多囊卵巢综合征(PCOS)不孕症患者的临床疗效及其安全性.方法 将2007年9月-2010年7月在我科就医的PCOS不孕患者108例,随机分为CC组、HMG组、CC+HMG组和LE组,每组27例,监测用药期间四组患者的促排卵情况、卵泡发育情况、子宫内膜厚度及其不良反应.结果 CC组有较高的排卵率,较低的妊娠率,子宫内膜厚度最薄,多胎妊娠率和OHSS风险较低;HMG组具有高排卵率、妊娠率,但多胎妊娠率和OHSS发生的危险性最高;LE组有较低排卵率、妊娠率,卵泡最小,多胎妊娠率和OHSS发生的危险性较低;CC+HMG组具有高排卵率、妊娠率,多胎妊娠率和OHSS发生的危险性较高.结论 四种促排卵法都有很好的促排卵作用,HMG和CC+HMG的妊娠率要高于LE和CC(P<0.05),但易导致OHSS和多胎妊娠,LE无论对卵泡生长还是对内膜生长都比较好且副作用低.但LE是否有潜在的胚胎致畸性有待进一步考证.
目的 比較不同促排卵方案治療多囊卵巢綜閤徵(PCOS)不孕癥患者的臨床療效及其安全性.方法 將2007年9月-2010年7月在我科就醫的PCOS不孕患者108例,隨機分為CC組、HMG組、CC+HMG組和LE組,每組27例,鑑測用藥期間四組患者的促排卵情況、卵泡髮育情況、子宮內膜厚度及其不良反應.結果 CC組有較高的排卵率,較低的妊娠率,子宮內膜厚度最薄,多胎妊娠率和OHSS風險較低;HMG組具有高排卵率、妊娠率,但多胎妊娠率和OHSS髮生的危險性最高;LE組有較低排卵率、妊娠率,卵泡最小,多胎妊娠率和OHSS髮生的危險性較低;CC+HMG組具有高排卵率、妊娠率,多胎妊娠率和OHSS髮生的危險性較高.結論 四種促排卵法都有很好的促排卵作用,HMG和CC+HMG的妊娠率要高于LE和CC(P<0.05),但易導緻OHSS和多胎妊娠,LE無論對卵泡生長還是對內膜生長都比較好且副作用低.但LE是否有潛在的胚胎緻畸性有待進一步攷證.
목적 비교불동촉배란방안치료다낭란소종합정(PCOS)불잉증환자적림상료효급기안전성.방법 장2007년9월-2010년7월재아과취의적PCOS불잉환자108례,수궤분위CC조、HMG조、CC+HMG조화LE조,매조27례,감측용약기간사조환자적촉배란정황、란포발육정황、자궁내막후도급기불량반응.결과 CC조유교고적배란솔,교저적임신솔,자궁내막후도최박,다태임신솔화OHSS풍험교저;HMG조구유고배란솔、임신솔,단다태임신솔화OHSS발생적위험성최고;LE조유교저배란솔、임신솔,란포최소,다태임신솔화OHSS발생적위험성교저;CC+HMG조구유고배란솔、임신솔,다태임신솔화OHSS발생적위험성교고.결론 사충촉배란법도유흔호적촉배란작용,HMG화CC+HMG적임신솔요고우LE화CC(P<0.05),단역도치OHSS화다태임신,LE무론대란포생장환시대내막생장도비교호차부작용저.단LE시부유잠재적배태치기성유대진일보고증.
Objective To compare the efficacy and safety of different therapies for sterile women with polycystic ovary syndrome ( PCOS ). Methods 108 sterile women with PCOS who had had medical visits during September 2007 and July 2010 were randomized to CC group, HMG group, CC/HMG group, or LE group, 27 women for each group. Ovulation induction, follicular development, endometrial thickness, and adverse reactions were observed. Results CC group had a higher rate of ovulation but lower rate of pregnancy, thinnest endometrial thickness, and a lower multiple pregnancy rate and OHSS risks. HMG group had higher rates of ovulation and pregnancy, and highest risks of multiple pregnancy and OHSS. LE group had lower rates of ovulation and pregnancy, smallest size of follicles, and lower risks of multiple pregnancy and OHSS. CC/HMG group had higher rates of ovulation, pregnancy, multiple pregnancy, and OHSS risk. Conclusions Four therapies have positive effects on ovulation. HMG and CC plus HMG could result in a higher rate of pregnancy and higher risks of multiple pregnancy and OHSS. LE has a positive effect on the development of follicles and endometrium,but has possible teratogenicity.
