CAJ | 학술논문

目的探讨粒系集落刺激因子(G-CSF)的调节机制及代谢途径。方法本文运用酶联免疫吸附试验（ELISA）检测61例慢性肾功能衰竭(CRF)+/-血液透析患者血清G-CSF水平。结果 CRF患者血清G-CSF水平明显升高。CRF非血透患者血清G-CSF检出率为80.65%,血清G-CSF水平为566.40±207.98ng/L。CRF血透患者G-CSF检出率为93.33%,血透前和血透后G-CSF水平分别为1255.36±611.25ng/L和1151.61±599.47ng/L。血透组G-CSF水平略高于非血透组,但两组无明显差异。血透前与血透后患者G-CSF水平无明显差异。进一步分析表明，G-CSF水平与WBC，BUN或Scr水平无关（P>0.05）。结论 CRF患者血清G-CSF水平升高可能是由于肾功能不全导致G-CSF清除减少或/和G-CSF产生增加。
목적탐토립계집락자격인자(G-CSF)적조절궤제급대사도경。 방법본문운용매련면역흡부시험（ELISA）검측61례만성신공능쇠갈(CRF)+/-혈액투석환자혈청G-CSF수평。 결과 CRF환자혈청G-CSF수평명현승고。CRF비혈투환자혈청G-CSF검출솔위80.65%,혈청G-CSF수평위566.40±207.98ng/L。CRF혈투환자G-CSF검출솔위93.33%,혈투전화혈투후G-CSF수평분별위1255.36±611.25ng/L화1151.61±599.47ng/L。혈투조G-CSF수평략고우비혈투조,단량조무명현차이。혈투전여혈투후환자G-CSF수평무명현차이。진일보분석표명，G-CSF수평여WBC，BUN혹Scr수평무관（P>0.05）。 결론 CRF환자혈청G-CSF수평승고가능시유우신공능불전도치G-CSF청제감소혹/화G-CSF산생증가。
Objective　To gain a better understanding of the regulatory mechanism and kinetic behaviour of granulocyte colony-stimulating factor (G-CSF). Methods　An enzyme-linked immunosorbent assay (ELISA) method was used to detect serum G-CSF in 61 patients with chronic renal failure±long-term hemodialysis and 30 normal controls. Results　Serum G-CSF levels in CRF patients were significantly higher than in normal controls. Eighty percent of patients had detectable G-CSF and serum G-CSF levels were 566.40±207.98?ng/L in non-hemodialyzed (non-HD) patients. The detectable percentage in hemodialyzed patients was 93.33%, serum G-CSF levels in pre-HD and post-HD patients were 1255.36±611.25?ng/L and 1151.61±599.47?ng/L respectively. Serum G-CSF levels in HD patients were slightly higher than in non-HD patients, but no significant difference was found between the two groups. No difference was found between the G-CSF values obtained in pre-HD and post-HD patients. There was no relationship between G-CSF levels and WBC, BUN or Scr (P>0.05). Conclusion　The high value of G-CSF in patients with CRF may be caused by a decrease in G-CSF clearance and/or an increase in G-CSF release.