CAJ | 학술논문

目的探讨性激素受体在胆囊癌中的表达。方法采用免疫组织化学Avidin Biotin Peroxidase Complex (ABC)方法对 106例胆囊癌和61例胆囊良性病变石蜡切片标本进行雌激素、孕激素及雄激素受体检测。结果胆囊癌中三种受体阳性率分别为67%、57%、44%。性激素受体阳性率与胆囊癌分化程度有密切关系。结论性激素与胆囊癌发展关系密切。内分泌治疗可能成为治疗胆囊癌的一种方法。
목적탐토성격소수체재담낭암중적표체。방법채용면역조직화학Avidin Biotin Peroxidase Complex (ABC)방법대 106례담낭암화61례담낭량성병변석사절편표본진행자격소、잉격소급웅격소수체검측。결과담낭암중삼충수체양성솔분별위67%、57%、44%。성격소수체양성솔여담낭암분화정도유밀절관계。결론성격소여담낭암발전관계밀절。내분비치료가능성위치료담낭암적일충방법。
Objective　To study the expression of sex hormone receptors in human gallbladder cancer.　 Methods　Using immunohistochemistry avidin biotin peroxidase complex（ABC) method, the expression of estrogen receptor (ER)、 progesterone receptor (PR) and androgen receptor (AR) was examined in paraffin embedded sections of gallbladder cancer in 106 cases and 61 benign controls.　Results　The positive expression rate of ER、 PR and AR in gallbladder cancer was 67%、57% and 44% respectively. The positive rates of sex hormone receptors had significant correlation with pathologic differentiation grade. 　Conclusion　There was significant correlations between sex hormones and the development of gallbladder cancer. Sex hormones might be implicated in the therapy of gallbladder cancer.