中华物理医学与康复杂志
中華物理醫學與康複雜誌
중화물리의학여강복잡지
CHINESE JOURNAL OF PHYSICAL MEDICINE AND REHABILITATION
2010年
12期
898-901
,共4页
脉冲电磁场%磁场强度%去势大鼠%生物力学特性
脈遲電磁場%磁場彊度%去勢大鼠%生物力學特性
맥충전자장%자장강도%거세대서%생물역학특성
Pulsed electromagnetic fields%Magnetic field intensity%Ovariectomized rats%Biomechanical properties
目的 研究不同强度低频脉冲电磁场对骨质疏松大鼠骨生物力学指标的影响,探讨脉冲电磁场治疗骨质疏松的最适强度.方法 按随机分组原则将50只雌性3月龄Sprague-Dawley大鼠分为5组:假手术对照组、模型对照组、0.77 mT组、3.82 mT组和9.87 mT组,每组10只.除假手术对照组以外,对各组动物去势造模.0.77 mT组、3.82 mT组和9.87 mT组大鼠每天在频率为8 Hz,磁感应强度分别为0.77 mT、3.82 mT和9.87 mT的磁场环境中干预40 min,共30 d.假手术对照组和模型对照组不干预.各组动物均于术后喂养30 d后股动脉放血处死,取右侧股骨测定生物力学特性(包括最大载荷、最大位移、最大能量吸收、最大应力、最大应变和弹性模量).结果 3.82 mT组各项生物力学指标与模型对照组和0.77 mT组比较,差异有统计学意义(P＜0.05);3.82 mT组最大位移、最大能量吸收、最大应力、弹性模量与9.87 mT组比较,差异有统计学意义(P＜0.05).结论 磁感应强度为3.82 mT的PEMFs能明显改善骨质疏松模型大鼠股骨生物力学特性.
目的 研究不同彊度低頻脈遲電磁場對骨質疏鬆大鼠骨生物力學指標的影響,探討脈遲電磁場治療骨質疏鬆的最適彊度.方法 按隨機分組原則將50隻雌性3月齡Sprague-Dawley大鼠分為5組:假手術對照組、模型對照組、0.77 mT組、3.82 mT組和9.87 mT組,每組10隻.除假手術對照組以外,對各組動物去勢造模.0.77 mT組、3.82 mT組和9.87 mT組大鼠每天在頻率為8 Hz,磁感應彊度分彆為0.77 mT、3.82 mT和9.87 mT的磁場環境中榦預40 min,共30 d.假手術對照組和模型對照組不榦預.各組動物均于術後餵養30 d後股動脈放血處死,取右側股骨測定生物力學特性(包括最大載荷、最大位移、最大能量吸收、最大應力、最大應變和彈性模量).結果 3.82 mT組各項生物力學指標與模型對照組和0.77 mT組比較,差異有統計學意義(P＜0.05);3.82 mT組最大位移、最大能量吸收、最大應力、彈性模量與9.87 mT組比較,差異有統計學意義(P＜0.05).結論 磁感應彊度為3.82 mT的PEMFs能明顯改善骨質疏鬆模型大鼠股骨生物力學特性.
목적 연구불동강도저빈맥충전자장대골질소송대서골생물역학지표적영향,탐토맥충전자장치료골질소송적최괄강도.방법 안수궤분조원칙장50지자성3월령Sprague-Dawley대서분위5조:가수술대조조、모형대조조、0.77 mT조、3.82 mT조화9.87 mT조,매조10지.제가수술대조조이외,대각조동물거세조모.0.77 mT조、3.82 mT조화9.87 mT조대서매천재빈솔위8 Hz,자감응강도분별위0.77 mT、3.82 mT화9.87 mT적자장배경중간예40 min,공30 d.가수술대조조화모형대조조불간예.각조동물균우술후위양30 d후고동맥방혈처사,취우측고골측정생물역학특성(포괄최대재하、최대위이、최대능량흡수、최대응력、최대응변화탄성모량).결과 3.82 mT조각항생물역학지표여모형대조조화0.77 mT조비교,차이유통계학의의(P＜0.05);3.82 mT조최대위이、최대능량흡수、최대응력、탄성모량여9.87 mT조비교,차이유통계학의의(P＜0.05).결론 자감응강도위3.82 mT적PEMFs능명현개선골질소송모형대서고골생물역학특성.
Objective To observe the effect of pulsed electromagnetic fields (PEMFs) of different intensities on the biomechanical properties of the femur in ovariectomized rats so as to determine the intensity for the best therapeutic efficacy. Methods Fifty female Sprague-Dawley rats were randomly divided into (1) a sham-operated control group (no PEMF treatment) , (2) ovariectomized control group (no PEMF treatment) (3) ovariectomized group Ⅰ (PEMF treatment at 8 Hz and 0.77 mT intensity, 40 min daily for 30 days) (4) ovariectomized group Ⅱ (PEMF treatment at 8 Hz and 3.82 mT intensity, 40 min daily for 30 days) and (5) ovariectomized group Ⅲ( PEMF treatment at 8 Hz and 9.87 mT intensity, 40 min daily for 30 days). Except for the 10 rats of the sham-operated control group, all the others received a standard ovariectomy. Serum estradiol (E2) and the biomechanical properties of one femur (peak load, maximum displacement, maximum energy absorption, maximum stress, maximum strain and modulus of elasticity) were assessed after 30 days of PEMF treatment. Results In group Ⅱ the biomechanical properties of the femur were significantly better than in group Ⅰ or the ovariectomized control group. In groups Ⅰ and Ⅲ the biomechanical properties of the femur were not significantly better than in the sham-operated group. In group Ⅱ the biomechanical properties of the femur were significantly better than in groups Ⅰ or Ⅲ. Conclusion PEMFs at 3.82 mT can improve the biomechanical properties of the femur significantly.
