CAJ | 학술논문

目的探讨血清硒水平与儿童腹泻病的关系,为临床治疗提供依据.方法选取6～24月龄腹泻病患儿78例,其中急性腹泻(AD)组30例,迁延性腹泻(PD)组26例,慢性腹泻(CD)组22例,对照组为健康体检儿童30例,分别测定血清硒水平.CD组病情恢复1个月后复查血清硒水平.结果 AD组血清硒水平为(51.34±4.84) μg/L,PD组血清硒水平为(48.14±3.05) μg/L,与对照组(55.08 ±5.59)μg/L比较差异无统计学意义(P＞0.05)；而CD组患儿血清硒水平为(42.13±5.16) μg/L,显著低于对照组(P＜0.05).CD组病情恢复1个月后复查其血清硒水平,为(53.76±8.38) μg/L,较治疗前血清硒水平明显升高,差异有统计学意义(P＜0.05).结论慢性腹泻的发生发展可能与硒缺乏有关,慢性腹泻的治疗应注重硒的补充.
목적 탐토혈청서수평여인동복사병적관계,위림상치료제공의거.방법 선취6～24월령복사병환인78례,기중급성복사(AD)조30례,천연성복사(PD)조26례,만성복사(CD)조22례,대조조위건강체검인동30례,분별측정혈청서수평.CD조병정회복1개월후복사혈청서수평.결과 AD조혈청서수평위(51.34±4.84) μg/L,PD조혈청서수평위(48.14±3.05) μg/L,여대조조(55.08 ±5.59)μg/L비교차이무통계학의의(P＞0.05)；이CD조환인혈청서수평위(42.13±5.16) μg/L,현저저우대조조(P＜0.05).CD조병정회복1개월후복사기혈청서수평,위(53.76±8.38) μg/L,교치료전혈청서수평명현승고,차이유통계학의의(P＜0.05).결론 만성복사적발생발전가능여서결핍유관,만성복사적치료응주중서적보충.
Objective To explore the relationship of the level of serum selenium and infantile diarrhea,provide foundation for establishing the therapeutic criteria.Methods Seventy-eight diarrhea children was enrolled in this study,6 -24 months old.Thirty children with acute diarrhea (AD group),26 children with persistent diarrhea (PD group) and 22 children with chronic diarrhea (CD group).The level of serum selenium was measured and compared with another 30 healthy children (control group) of matched sex and age.The level of serum selenium of CD group was compared before and after the recovery.Results The level of serum selenium in AD group and PD group had no significant difference compared with control group [ (51.34 ± 4.84),(48.14 ± 3.05 ) μ g/L vs.(55.08 ± 5.59 ) μ g/L ] (P＞0.05 ).But the level of serum selenium in CD group was significantly lower than that in control group [ (42.13 ± 5.16) μ g/L vs.(55.08 ±5.59) μg/L] (P＜0.05).After treatment for 1 month,the level of serum selenium in CD group was significantly increased than before treatment [ (53.76 ± 8.38 ) μ g/L vs.(42.13 ± 5.16) μ g/L ] (P＜0.05 ).Conclusions The nosogenesis of chronic diarrhea may relate with the level of serum selenium decrease.Therapeutic selenium supplement is important in children with chronic diarrhea.