广东化工
廣東化工
엄동화공
GUANGDONG CHEMICAL INDUSTRY
2012年
2期
20-21
,共2页
刘平%刘剑平%林尤宜%唐志姣%龚福春
劉平%劉劍平%林尤宜%唐誌姣%龔福春
류평%류검평%림우의%당지교%공복춘
5-羟基吲哚%相转移催化剂%工艺
5-羥基吲哚%相轉移催化劑%工藝
5-간기신타%상전이최화제%공예
5-Hydroxyl indole%pHase transfer catalyst%synthesis
介绍了一种以吲哚为原料合成5-羟基吲哚的新方法。该方法采用磺酸基保护吲哚活泼3位,取代吲哚5位获得了5-溴吲哚,经水解合成目标物。本方法首次采用相转移催化剂实现了5-溴吲哚得高效率水解。优化了合成工艺：反应物乙酸酐与2-磺酸钠-二氢吲哚一水合物的摩尔配比为20∶1,pH为11,选用四甲基氯化铵相转移催化剂,产物得率达到了81.2%。
介紹瞭一種以吲哚為原料閤成5-羥基吲哚的新方法。該方法採用磺痠基保護吲哚活潑3位,取代吲哚5位穫得瞭5-溴吲哚,經水解閤成目標物。本方法首次採用相轉移催化劑實現瞭5-溴吲哚得高效率水解。優化瞭閤成工藝：反應物乙痠酐與2-磺痠鈉-二氫吲哚一水閤物的摩爾配比為20∶1,pH為11,選用四甲基氯化銨相轉移催化劑,產物得率達到瞭81.2%。
개소료일충이신타위원료합성5-간기신타적신방법。해방법채용광산기보호신타활발3위,취대신타5위획득료5-추신타,경수해합성목표물。본방법수차채용상전이최화제실현료5-추신타득고효솔수해。우화료합성공예：반응물을산항여2-광산납-이경신타일수합물적마이배비위20∶1,pH위11,선용사갑기록화안상전이최화제,산물득솔체도료81.2%。
Indole was prepared from 5-Hydroxyl indole.The third position on the ring of indole was protected by reaction with the group of sulfonic acid.Then 5-bromine indole was synthesized from the indole derivative.At last the target was synthesised by the reaction of hydrolysis. Phase transfer catalyst was used to the hydrolysis of 5-bromine indole first.The optimum conditions were： the reactant ratio of Acetic anhydride to 2-sulfonic acid sodium indole was 20 ∶1,pH was 11,pHase transfer catalyst was Tetramethyl ammonium chloride,and the yield was 81.2 %.
