中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2009年
5期
480-482
,共3页
叶辉%叶千琨%董桂霞%周向京%田耕%李瑛%黄耀辉
葉輝%葉韆琨%董桂霞%週嚮京%田耕%李瑛%黃耀輝
협휘%협천곤%동계하%주향경%전경%리영%황요휘
不稳定型心绞痛%四氢叶酸还原酶%基因%多态性
不穩定型心絞痛%四氫葉痠還原酶%基因%多態性
불은정형심교통%사경협산환원매%기인%다태성
Unstable angina pectoris%Methylenetetrahydrofolate reductase%Gene%Polymorphism
目的 探讨四氢叶酸还原酶(MTHFR)基因C677T变异与中国人群不稳定型心绞痛(UA)的关系.方法 随机收集90例UA患者(UA组),并收集与之年龄、性别相匹配的90例体检健康对照人群(对照组),采用聚合酶链反应-限制性片段多态性(PCR-RFLP)方法 进行MTHFR基因C677T变异的分析.观察不稳定型心绞痛与MTHFR基因C677T多态性的关系.结果 UA组MTHFR基因677TT纯合子为9例,C677T杂合子为21例,突变率33.33%;对照组MTHFR基因677TT纯合子为3例,C677T杂合子为12例,突变率16.67%;结果 显示2组MTHFR基因C677T变异差别有统计学意义(P<0.05).结论 MTHFR基因C677T变异与中国人群不稳定型心绞痛的发生相关.
目的 探討四氫葉痠還原酶(MTHFR)基因C677T變異與中國人群不穩定型心絞痛(UA)的關繫.方法 隨機收集90例UA患者(UA組),併收集與之年齡、性彆相匹配的90例體檢健康對照人群(對照組),採用聚閤酶鏈反應-限製性片段多態性(PCR-RFLP)方法 進行MTHFR基因C677T變異的分析.觀察不穩定型心絞痛與MTHFR基因C677T多態性的關繫.結果 UA組MTHFR基因677TT純閤子為9例,C677T雜閤子為21例,突變率33.33%;對照組MTHFR基因677TT純閤子為3例,C677T雜閤子為12例,突變率16.67%;結果 顯示2組MTHFR基因C677T變異差彆有統計學意義(P<0.05).結論 MTHFR基因C677T變異與中國人群不穩定型心絞痛的髮生相關.
목적 탐토사경협산환원매(MTHFR)기인C677T변이여중국인군불은정형심교통(UA)적관계.방법 수궤수집90례UA환자(UA조),병수집여지년령、성별상필배적90례체검건강대조인군(대조조),채용취합매련반응-한제성편단다태성(PCR-RFLP)방법 진행MTHFR기인C677T변이적분석.관찰불은정형심교통여MTHFR기인C677T다태성적관계.결과 UA조MTHFR기인677TT순합자위9례,C677T잡합자위21례,돌변솔33.33%;대조조MTHFR기인677TT순합자위3례,C677T잡합자위12례,돌변솔16.67%;결과 현시2조MTHFR기인C677T변이차별유통계학의의(P<0.05).결론 MTHFR기인C677T변이여중국인군불은정형심교통적발생상관.
Objective To explore the relationship between methylenetetra hydrofolate reduetase (MTHFR) C677T genotypo and unstable angina pectoris(UA) in Chinese population. Methods The study consisted of 90 UA cases (UA group), and an age- and sex- matched healthy control cases (control group, n = 90). PC R-RFLP was used to analyze polymorphism of the MTHFR C677T genotypo. The relationship between MTHFR C677T genotype and UA was observed. Results MTHFR 677C→T mutation was found in 30 of 90 patients with unstable angina pectoris (33.33%) and in 15 of 90 control subjects (16.67%). This difference was statistically significant (P<0.05). Conclusion MTHFR 677C→T mutation is closely related to the unstable angina poctoris.
