国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2008年
9期
718-720
,共3页
宫颈肿瘤%综合疗法
宮頸腫瘤%綜閤療法
궁경종류%종합요법
Cervixneoplasms%Combined modality therapy
目的 评价低剂量顺铂(DDP)+5-氟尿嘧啶(5-Fu)周疗同步放疗治疗中晚期宫颈癌的疗效和不良反应.方法 73例中晚期宫颈癌患者随机分为化放组(37例)和单放组(36例).化放组放疗同期每周接受1次DDP 40 mg+5-FU 500 mg化疗,连用6～7周;单放组行单纯放疗.两组放疗均采用常规分割,总剂量50 Gy.结果 化放组与单放组总有效率、3年生存率、局部复发率、远处转移率分别为97.30%和77.78%、89.19%和66.67%、8.11%和30.56%、10.81%和33.33%,两组对比差异均有统计学意义(P<0.05),骨髓抑制及消化道反应发生率化放组均高于单放组,多为Ⅰ、Ⅱ级.结论 低剂量DDP+5-FU周疗同步放疗治疗中晚期宫颈癌可显著提高患者的局部控制率和生存率,不良反应轻.
目的 評價低劑量順鉑(DDP)+5-氟尿嘧啶(5-Fu)週療同步放療治療中晚期宮頸癌的療效和不良反應.方法 73例中晚期宮頸癌患者隨機分為化放組(37例)和單放組(36例).化放組放療同期每週接受1次DDP 40 mg+5-FU 500 mg化療,連用6～7週;單放組行單純放療.兩組放療均採用常規分割,總劑量50 Gy.結果 化放組與單放組總有效率、3年生存率、跼部複髮率、遠處轉移率分彆為97.30%和77.78%、89.19%和66.67%、8.11%和30.56%、10.81%和33.33%,兩組對比差異均有統計學意義(P<0.05),骨髓抑製及消化道反應髮生率化放組均高于單放組,多為Ⅰ、Ⅱ級.結論 低劑量DDP+5-FU週療同步放療治療中晚期宮頸癌可顯著提高患者的跼部控製率和生存率,不良反應輕.
목적 평개저제량순박(DDP)+5-불뇨밀정(5-Fu)주료동보방료치료중만기궁경암적료효화불량반응.방법 73례중만기궁경암환자수궤분위화방조(37례)화단방조(36례).화방조방료동기매주접수1차DDP 40 mg+5-FU 500 mg화료,련용6～7주;단방조행단순방료.량조방료균채용상규분할,총제량50 Gy.결과 화방조여단방조총유효솔、3년생존솔、국부복발솔、원처전이솔분별위97.30%화77.78%、89.19%화66.67%、8.11%화30.56%、10.81%화33.33%,량조대비차이균유통계학의의(P<0.05),골수억제급소화도반응발생솔화방조균고우단방조,다위Ⅰ、Ⅱ급.결론 저제량DDP+5-FU주료동보방료치료중만기궁경암가현저제고환자적국부공제솔화생존솔,불량반응경.
Objective To evaluate the therapeutic efficiency and side effect of concurrent radiotherapy and weekly chemotherapy with low-dose eisplatin(DDP) and 5-fluorouracil(5-FU) for advanced cervical canc-er. Methods 73 patients with advanced cervical cancer were randomized into two groups: 37 cases in the chemo-radiotherapy group received radiotherapy combined with DDP 40 mg and 5-FU 500 mg weekly for 6-7 weeks. 36 cases in the only radiotherapy group received radiotherapy alone. Radiotherapy was given with conven-tional fraction,the total tumor dose was 50 Gy. Results The rate of overall response and three-year survival and local recurrenc and distant metastasis for the chemo-radiotherapy group and the only radiotherapy group were 97.30%, 89. 19%, 8. 11% and 10. 81%, and those for the only radiotherapy group were 77.78%,66. 67% ,30.56% and 33.33%. The difference of the four groups was statistically significant ( P <0. 05). The rate of bone marrow inhibition and reaction of digestive tract in chemo-radiotherapy group were higher than those in simple radiotherapy group, but most reactions were grade 1 and grade 2, without statistically significant dife-renee between two groups. Conclusion Concurrent radiotherapy and weekly chemotherapy with low-dose cis-platin and 5-fluorouracil for advanced cervical cancer can significantly improve local control rate and survival rate, and have slight side effects.
