CAJ | 학술논문

通过固体分散体技术采用熔融硬脂酸包裹进行掩味,制备出口感较好的干混悬剂,并符合中国药典要求。采用硬脂酸为掩味材料,加热熔融后混入头孢呋辛酯制备成固体分散体,再进行干混悬剂的制备,并对其处方的最佳比例及其它组分的比例进行了实验筛选。结果表明,采用将2∶1的头孢呋辛酯原料加入75℃加热熔融的硬脂酸中,搅拌均匀粉碎后加入1.5%黄原胶,可以很好地掩盖头孢呋辛酯的苦味,同时能符合中国药典对干混悬剂的要求。
통과고체분산체기술채용용융경지산포과진행엄미,제비출구감교호적간혼현제,병부합중국약전요구。채용경지산위엄미재료,가열용융후혼입두포부신지제비성고체분산체,재진행간혼현제적제비,병대기처방적최가비례급기타조분적비례진행료실험사선。결과표명,채용장2∶1적두포부신지원료가입75℃가열용융적경지산중,교반균균분쇄후가입1.5%황원효,가이흔호지엄개두포부신지적고미,동시능부합중국약전대간혼현제적요구。
To cover bitterness by solid dispersion technology and melted stearic acid for preparing cefuroxime axetil for suspension which complies with the Chinese Pharmacopeia requirements.Cefuroxime axetil was mixed into melted stearic acid,which was the component to cover the bitter taste,and then the finished drug product was made with this solid mixture.The formulation was also optimized through well designed experiments.Result showed that with 75 ℃ melted stearic acid wrapping by 2∶1 ratio;the bitterness of cefuroxime axetil could be well covered,and with 1.5% xanthan gum as suspension aid,the finished drug product compling with CP was obtained.