CAJ | 학술논문

目的探讨亚叶酸钙与碳酸氢钠溶液交替含漱预防大剂量甲氨蝶呤所致口腔溃疡的效果.方法将60例大剂量甲氨蝶呤化疗的患儿随机分为实验组及对照组,每组30例.对照组给予生理盐水含漱,实验组给予0.1%亚叶酸钙与1%碳酸氢钠溶液交替漱口.观察两组患者口腔溃疡发生率及溃疡发生程度.结果实验组口腔溃疡发生率、程度明显低于对照组,两者比较差异有显著差异(P<0.01).结论大剂量甲氨蝶呤化疗的患儿使用0.1%亚叶酸钙与1%碳酸氢钠溶液交替漱口,可以有效预防口腔溃疡的发生.
목적 탐토아협산개여탄산경납용액교체함수예방대제량갑안접령소치구강궤양적효과.방법 장60례대제량갑안접령화료적환인수궤분위실험조급대조조,매조30례.대조조급여생리염수함수,실험조급여0.1%아협산개여1%탄산경납용액교체수구.관찰량조환자구강궤양발생솔급궤양발생정도.결과 실험조구강궤양발생솔、정도명현저우대조조,량자비교차이유현저차이(P<0.01).결론 대제량갑안접령화료적환인사용0.1%아협산개여1%탄산경납용액교체수구,가이유효예방구강궤양적발생.
Objective To explore the effectiveness of preventing oral ulcer by using high dose methotrexate with calcium folinate and sodium bicarbonate gargle alternatively.Methods Sixty patients of high dose methotrexate chemotherapy were randomly divided into experiment group and control group, with 30 patients in each group, Normal saline was given to those in the control group for gargle, and calcium folinate and sodium bicarbonate gargle alternatively for those in the experiment group, The incidence and grade of oral ulcer were observed.Results The incidence of oral ulcer and grade were markedly lower in the experiment group than that in control group. The difference between the two groups was significant(P<0.01).Conclusions Alternate gargling with calcium folinate and sodium bicarbonate is effective in the prevention of incidence of oral ulcer in patients with high dose methotrexate chemotherapy.