CAJ | 학술논문

本文用放射免疫法分别测定了流行性乙型脑炎(乙脑)患者极期、昏迷刚醒时、恢复期血及脑脊液(OSF)中亮氨酸脑啡肽(Leu-脑啡肽)值.结果发现患者在乙脑极期时血Leu-脑啡肽为159.2±25.45pg/ml(N=15),比正常值86.5±9.2pg/ml(N=15)明显升高(P<0.001).CSF中Leu-脑啡肽为211/=30.23pg/ml(N=8)与其正常值148.6±16.4pg/mi相比也明显升高(P<0.001).进入恢复期时均有所下降.各症状组的统计学分析提示乙脑中枢性高热、昏迷、抽搐、呼吸衰竭症状与血及CSF中Leu-脑啡呔升高有关.
본문용방사면역법분별측정료류행성을형뇌염(을뇌)환자겁기、혼미강성시、회복기혈급뇌척액(OSF)중량안산뇌배태(Leu-뇌배태)치.결과발현환자재을뇌겁기시혈Leu-뇌배태위159.2±25.45pg/ml(N=15),비정상치86.5±9.2pg/ml(N=15)명현승고(P<0.001).CSF중Leu-뇌배태위211/=30.23pg/ml(N=8)여기정상치148.6±16.4pg/mi상비야명현승고(P<0.001).진입회복기시균유소하강.각증상조적통계학분석제시을뇌중추성고열、혼미、추휵、호흡쇠갈증상여혈급CSF중Leu-뇌배태승고유관.
Leu-enkaphalin levels in the blood and CSF of patients with epidemic enoephalitis B during critioal and convalescent stages were measured by radioimmunoassay.It was found that the blood leu-enkaphalin levels in 15 patients at critical stage wero significantly higher (159.2+25.45 pg/ml)than normal level(86.5+9.2 pg/ml).The leu-eukaphalin levels in CSF of 8 patients during critical stage were found significantly incresed (211±30.28 pg/ml)(P<0.eel).When the patients were at convalescent stage,the leu-enkaphalin levels in blood and CSF were ineaeased.The statistioal analysis of symptoms suggested that high fever,coma, convulsion and respiratory failure of patients were associated with higher leu-enkaphalin levels in blood and OSF.These results imply that endogenoue opioid peptides may be involved in the physiopa thologic changes of epidemic encephalitis B.