中华传染病杂志
中華傳染病雜誌
중화전염병잡지
CHINESE JOURNAL OF INFECTIOUS DISEASES
1988年
4期
193-197
,共5页
姚光弼%陆选永%张利民%田月芬%吴晓红
姚光弼%陸選永%張利民%田月芬%吳曉紅
요광필%륙선영%장이민%전월분%오효홍
前S1和前S2蛋白%乙型肝炎病毒复制%乙型肝炎病毒脱氧核糖核酸和脱氧核糖核酸多聚酶
前S1和前S2蛋白%乙型肝炎病毒複製%乙型肝炎病毒脫氧覈糖覈痠和脫氧覈糖覈痠多聚酶
전S1화전S2단백%을형간염병독복제%을형간염병독탈양핵당핵산화탈양핵당핵산다취매
Pro-St and Pro-S2 proteins%HBV replication%HBV DNA and DNA-P
对63例乙型肝炎患者血清中前S1和前S2蛋白的研究表明,两者均与病毒的复制具有明显的相关性.41例前81蛋白阳性者中,HBeAg阳性为31例,占75.6%:45例前81蛋白阳性者中HBV白蛋白受体阳性为32例,占71.7%.35例前S2蛋白阳性者中,HBeAg阳性为27例,占77.1%;39例前S2蛋白阳性者中.HBV白蛋白受体阳性为30例,占77.0%.对前S1和前S2蛋白用HBV DNA,DNA-P的关系的研究也可得出相同的结论,以上结论表明前S1和前S2蛋白可以作为表达病毒活动性复制的新标志,并提示两者可能均涉及到病毒对肝细胞的附着过程.
對63例乙型肝炎患者血清中前S1和前S2蛋白的研究錶明,兩者均與病毒的複製具有明顯的相關性.41例前81蛋白暘性者中,HBeAg暘性為31例,佔75.6%:45例前81蛋白暘性者中HBV白蛋白受體暘性為32例,佔71.7%.35例前S2蛋白暘性者中,HBeAg暘性為27例,佔77.1%;39例前S2蛋白暘性者中.HBV白蛋白受體暘性為30例,佔77.0%.對前S1和前S2蛋白用HBV DNA,DNA-P的關繫的研究也可得齣相同的結論,以上結論錶明前S1和前S2蛋白可以作為錶達病毒活動性複製的新標誌,併提示兩者可能均涉及到病毒對肝細胞的附著過程.
대63례을형간염환자혈청중전S1화전S2단백적연구표명,량자균여병독적복제구유명현적상관성.41례전81단백양성자중,HBeAg양성위31례,점75.6%:45례전81단백양성자중HBV백단백수체양성위32례,점71.7%.35례전S2단백양성자중,HBeAg양성위27례,점77.1%;39례전S2단백양성자중.HBV백단백수체양성위30례,점77.0%.대전S1화전S2단백용HBV DNA,DNA-P적관계적연구야가득출상동적결론,이상결론표명전S1화전S2단백가이작위표체병독활동성복제적신표지,병제시량자가능균섭급도병독대간세포적부착과정.
The researches on HBV Pro-S1 and Pro-S2 proteins among 63 eases with chronic hepatitis B showed that the Pre-s gene products were closely correlated with the replication of virus.Among 41 Pre-Sl positive cases,31 eases were HBeAg positive(75.6%)and 32 of the 45 with Pre-S1 positive were PHSA-R positive.Similarly,among the 32 Pro-S2 positive cases,27 were HBeAg positive(77.1%)and 30 of the 32 Pre-S2 positive were PHSA-R positive.The present study also revealed tha there was positive correlation between Pre-S1 and Pro-S2 proteins and HBV DNA and DNA-p.These results suggested that the detection of Pre-S1 and Pro-S2 proteins could be used as the new markers of HBV replication.