中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2011年
9期
937-939
,共3页
肿瘤%医院感染%真菌%白色念珠菌%抗真菌药物
腫瘤%醫院感染%真菌%白色唸珠菌%抗真菌藥物
종류%의원감염%진균%백색념주균%항진균약물
Tumor%Infection in hospital%Fungi%Candida albicans%Antifungal drug
目的 分析肿瘤专科医院真菌的分布特点及耐药现状,为临床医师预防与控制真菌医院感染提供科学依据。方法 回顾性调查分析2006年4月至2010年11月间我院真菌的流行分布及药敏试验结果。结果 5年共分离到真菌1011株,检出率最高的是白色念珠菌(5年平均达41.6%),但其所占比例由2006年53.8%下降至2010年的31.7%,而其他非白色念珠菌却由2006年的46.2%增至2010年的68.3%;普外科、内科、肝胆外科和中西医科是检出菌珠数较多的科室;分离标本主要集中在痰和咽拭子,其次为血液标本;体外药敏试验结果表明:伏立康唑、两性霉素B和5-氟胞嘧啶的敏感性较高;伊曲康唑、氟康唑对念珠菌耐药性较强。结论 医院真菌感染病原菌分布已经发生变迁,且真菌的耐药率不断升高,应引起临床医师的高度重视。
目的 分析腫瘤專科醫院真菌的分佈特點及耐藥現狀,為臨床醫師預防與控製真菌醫院感染提供科學依據。方法 迴顧性調查分析2006年4月至2010年11月間我院真菌的流行分佈及藥敏試驗結果。結果 5年共分離到真菌1011株,檢齣率最高的是白色唸珠菌(5年平均達41.6%),但其所佔比例由2006年53.8%下降至2010年的31.7%,而其他非白色唸珠菌卻由2006年的46.2%增至2010年的68.3%;普外科、內科、肝膽外科和中西醫科是檢齣菌珠數較多的科室;分離標本主要集中在痰和嚥拭子,其次為血液標本;體外藥敏試驗結果錶明:伏立康唑、兩性黴素B和5-氟胞嘧啶的敏感性較高;伊麯康唑、氟康唑對唸珠菌耐藥性較彊。結論 醫院真菌感染病原菌分佈已經髮生變遷,且真菌的耐藥率不斷升高,應引起臨床醫師的高度重視。
목적 분석종류전과의원진균적분포특점급내약현상,위림상의사예방여공제진균의원감염제공과학의거。방법 회고성조사분석2006년4월지2010년11월간아원진균적류행분포급약민시험결과。결과 5년공분리도진균1011주,검출솔최고적시백색념주균(5년평균체41.6%),단기소점비례유2006년53.8%하강지2010년적31.7%,이기타비백색념주균각유2006년적46.2%증지2010년적68.3%;보외과、내과、간담외과화중서의과시검출균주수교다적과실;분리표본주요집중재담화인식자,기차위혈액표본;체외약민시험결과표명:복립강서、량성매소B화5-불포밀정적민감성교고;이곡강서、불강서대념주균내약성교강。결론 의원진균감염병원균분포이경발생변천,차진균적내약솔불단승고,응인기림상의사적고도중시。
Objective To investigate the flora distribution and drug resistance status of nosocomial fungal infection in cancer hospitals for providing the scientific basis for clinical prevention and control.Methods The related clinical data and results of drug sensitivity tests of fungal infection in hospitalized patients from April 2006 to November 2010 were analyzed retrospectively.Results A total of 1011 strains of candida were isolated in five years, in which, Candida albicans (41.6% on average) were the highest detection rate strains.The proportion of Candida albicans declined from 53.8% in 2006 to 31.7% in 2010, while the other non-Candida albicans increased from 46.2% in 2006 to 68.3% in 2010.In the General surgery, the Internal medicine,the Hepatobiliary surgery, and the Chinese and Western medicine, the number of candida were more than the other departments.The specimens were mainly isolated from sputum and swab, followed by blood specimens.In vitro susceptibility test results showed that: voriconazole, amphotericin B and 5-fluorocytosine showed high sensitivity and itraconazole, fluconazole showed high drug resistance to albicans.Conclusion Distribution of pathogens causing nosocomial fungal infection has changed, and the rates of fungal resistance were rising,so this situation should arouse the clinician's attention.