河北省科学院学报
河北省科學院學報
하북성과학원학보
JOURNAL OF THE HEBEI ACADEMY OF SCIENCES
2011年
2期
58-61
,共4页
硝呋太尔%合成工艺%优化
硝呋太爾%閤成工藝%優化
초부태이%합성공예%우화
Nifuratel%Synthetic process%Optimization
对已有硝呋太尔合成工艺进行改进,直接采用市售的甲硫醇钠为原料,与环氧氯丙烷缩合得到甲硫基环氧丙烷。甲硫基环氧丙烷经过肼解、环合、缩合得到硝呋太尔。其中,肼解反应得到的肼解物不经分离直接进行环合反应,硝呋太尔收率比国内外文献报道高10%左右,降低了生产成本,适合工业化生产。
對已有硝呋太爾閤成工藝進行改進,直接採用市售的甲硫醇鈉為原料,與環氧氯丙烷縮閤得到甲硫基環氧丙烷。甲硫基環氧丙烷經過肼解、環閤、縮閤得到硝呋太爾。其中,肼解反應得到的肼解物不經分離直接進行環閤反應,硝呋太爾收率比國內外文獻報道高10%左右,降低瞭生產成本,適閤工業化生產。
대이유초부태이합성공예진행개진,직접채용시수적갑류순납위원료,여배양록병완축합득도갑류기배양병완。갑류기배양병완경과정해、배합、축합득도초부태이。기중,정해반응득도적정해물불경분리직접진행배합반응,초부태이수솔비국내외문헌보도고10%좌우,강저료생산성본,괄합공업화생산。
To improve the synthetic process of nifuratel,it used the commercially available 3-methylthio-（1,2-epoxypropane） as raw materials,condensated with PO to obtain Ethylthio-epoxy propane.This compound was then treated according to the known procedures such as hydrazinolysis and cyclization and condensation to form nifuratel.Products of hydrazinolysis reaction cyclizated directly without separation.By improving the synthetic process,the yield of compound nifuratel was exceeding 10% from what was reported.These reduced the cost of production and was suitable for the nifuratel production in factories.
