国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2012年
9期
791-793
,共3页
童皖宁%赵志宇%卓安山%曹玉书
童皖寧%趙誌宇%卓安山%曹玉書
동환저%조지우%탁안산%조옥서
银杏达莫注射液%血流流变学%凝血功能%慢性阻塞性肺疾病急性加重期
銀杏達莫註射液%血流流變學%凝血功能%慢性阻塞性肺疾病急性加重期
은행체막주사액%혈류류변학%응혈공능%만성조새성폐질병급성가중기
Ginkgo dipyridolum injection%Blood-rheological%Coagulation function%Chronic obstructive Pulmonary disease with acute exacerbation
目的 观察银杏达莫注射液对慢性阻塞性肺疾病急性加重期(chronic obstructive Pulmonary disease with acute exacerbation,AECOPD)患者血液流变学及凝血功能的影响.方法 78例AECOPD患者采用数字随机表法,被分成A、B两组,进行临床分析.A组38例,给予常规吸氧、解痉平喘、抗感染等对症治疗；B组40例,常规治疗基础上给予银杏达莫注射液(30ml,加入0.9％氯化钠250 ml中静滴,1次/d)治疗.观察患者血液流变学、凝血功能等改善情况.结果 在血液流变学方面,A组治疗后全血高切黏度(5.25±1.24) mPa·S、全血低切黏度(11.12±2.43) mPa·S、血浆黏度(2.06±0.14) mPa·S、红细胞压积(45.52±2.78)％,与B组[依次为(4.83±1.42) mPa·S、(8.78±3.02) mPa·S、(1.73±0.21) mPa·S、(39.05±3.41)％]比较,差异均有统计学意义(P均＜0.05)；在凝血功能指标方面,A组治疗后PT(13.14±1.31)S、APTT (30.85±5.24)S、FIB (4.99±1.04)S、D-D (1.42±0.23) mg/L,与B组[依次为(14.78±3.13)S、(36.67±8.12)S、(3.81±0.42)S、(0.84±0.39) mg/L]比较,差异均有统计学意义(P均＜0.05).结论 银杏达莫注射液可以显著降低AECOPD患者的血黏度,改善其血液高凝状态.
目的 觀察銀杏達莫註射液對慢性阻塞性肺疾病急性加重期(chronic obstructive Pulmonary disease with acute exacerbation,AECOPD)患者血液流變學及凝血功能的影響.方法 78例AECOPD患者採用數字隨機錶法,被分成A、B兩組,進行臨床分析.A組38例,給予常規吸氧、解痙平喘、抗感染等對癥治療；B組40例,常規治療基礎上給予銀杏達莫註射液(30ml,加入0.9％氯化鈉250 ml中靜滴,1次/d)治療.觀察患者血液流變學、凝血功能等改善情況.結果 在血液流變學方麵,A組治療後全血高切黏度(5.25±1.24) mPa·S、全血低切黏度(11.12±2.43) mPa·S、血漿黏度(2.06±0.14) mPa·S、紅細胞壓積(45.52±2.78)％,與B組[依次為(4.83±1.42) mPa·S、(8.78±3.02) mPa·S、(1.73±0.21) mPa·S、(39.05±3.41)％]比較,差異均有統計學意義(P均＜0.05)；在凝血功能指標方麵,A組治療後PT(13.14±1.31)S、APTT (30.85±5.24)S、FIB (4.99±1.04)S、D-D (1.42±0.23) mg/L,與B組[依次為(14.78±3.13)S、(36.67±8.12)S、(3.81±0.42)S、(0.84±0.39) mg/L]比較,差異均有統計學意義(P均＜0.05).結論 銀杏達莫註射液可以顯著降低AECOPD患者的血黏度,改善其血液高凝狀態.
목적 관찰은행체막주사액대만성조새성폐질병급성가중기(chronic obstructive Pulmonary disease with acute exacerbation,AECOPD)환자혈액류변학급응혈공능적영향.방법 78례AECOPD환자채용수자수궤표법,피분성A、B량조,진행림상분석.A조38례,급여상규흡양、해경평천、항감염등대증치료；B조40례,상규치료기출상급여은행체막주사액(30ml,가입0.9％록화납250 ml중정적,1차/d)치료.관찰환자혈액류변학、응혈공능등개선정황.결과 재혈액류변학방면,A조치료후전혈고절점도(5.25±1.24) mPa·S、전혈저절점도(11.12±2.43) mPa·S、혈장점도(2.06±0.14) mPa·S、홍세포압적(45.52±2.78)％,여B조[의차위(4.83±1.42) mPa·S、(8.78±3.02) mPa·S、(1.73±0.21) mPa·S、(39.05±3.41)％]비교,차이균유통계학의의(P균＜0.05)；재응혈공능지표방면,A조치료후PT(13.14±1.31)S、APTT (30.85±5.24)S、FIB (4.99±1.04)S、D-D (1.42±0.23) mg/L,여B조[의차위(14.78±3.13)S、(36.67±8.12)S、(3.81±0.42)S、(0.84±0.39) mg/L]비교,차이균유통계학의의(P균＜0.05).결론 은행체막주사액가이현저강저AECOPD환자적혈점도,개선기혈액고응상태.
Objective To evaluate the influence of ginkgo dipyridolum injection on blood-rheological and coagulation function in pationts with AECOPD.Methods 78 cases of patients with AECOPD were divided into group A (38 cases)and group B (40 cases)by mean of digital random table method.The routine treatment including oxygen inhalation,spasmolytics and anti-infection was given to patients in both groups while ginkgo dipyridolum injection (30 ml/d)was additionally added to patients in group B for two weeks.The blood-rheological and coagulation function were evaluated.Results As for blood-rheological after the treatment,whole blood high shearing viscosity(5.25 ± 1.24)mPa · S,low shearing viscosity (11.12 ±2.43) mPa · S,plasma viscosity (2.06± 0.14 ) mPa · S and hematocrit (45.52 ± 2.78) ％ in the group A indicated significant differences compared to those in group B [ (4.83 ± 1.42)mPa· S,(8.78± 3.02) mPa · S,(1.73 ±0.21) mPa · S,(39.05 ± 3.41) ％],(P＜0.05); as for coagulation function after the treatment,PT (13.14± 1.31 ) S,APTT (30.85±5.24)S,FIB (4.99±1.04)S,D-D (1.42±0.23)mg/L in the group A indicated significant differences compared to those in group B [ (14.78 ± 3.13) S,(36.67 ± 8.12)S,(3.81 ± 0.42) S,(0.84 ±0.39) mg/L],(P＜0.05).Conclusion For the patients with AECOPD,the ginkgo dipyridolum injection can decrease hood-viscosity,and obviously improve hypercoagulabale state.
