CAJ | 학술논문

目的探讨神经发育危险因素与精神分裂症发病的关系。方法采用病前分裂样及分裂型特质量表（PSST）和病前社会适应量表（PSA），对166个家系中的310例精神分裂症患者（患者组）及307名正常同胞（对照组）进行评定和病例-对照研究，并将所有研究对象以PSST和PSA评分按照1/3位数划分为高分组、中分组、低分组进行比较。对两组神经发育危险因素进行单因素及多因素Logistic回归模型分析。结果（1）经病例-对照分析，高热惊厥及婴幼儿期患严重疾病与精神分裂症的发生有关［比数比（OR）值分别为6.05和2.64，P值为0.02和0.01］；经多因素Logistic回归模型分析，亦提示这两个因素与精神分裂症的发病有关（高热惊厥的OR=4.7，P=0.06，婴幼儿期患严重疾病的OR=2.7，P=0.02）。（2）高热惊厥、婴幼儿期患严重疾病与PSST和/或PSA高分数有一定关系。PSST及PSA的高分和中分者患精神分裂症的机会较低分者增加（P<0.001）。结论高热惊厥及婴幼儿期患严重疾病可能增加精神分裂症的易感性，这两个因素可能与儿童、青少年期的个性和社会适应不良有关。
목적탐토신경발육위험인소여정신분렬증발병적관계。방법채용병전분렬양급분렬형특질량표（PSST）화병전사회괄응량표（PSA），대166개가계중적310례정신분렬증환자（환자조）급307명정상동포（대조조）진행평정화병례-대조연구，병장소유연구대상이PSST화PSA평분안조1/3위수화분위고분조、중분조、저분조진행비교。대량조신경발육위험인소진행단인소급다인소Logistic회귀모형분석。결과（1）경병례-대조분석，고열량궐급영유인기환엄중질병여정신분렬증적발생유관［비수비（OR）치분별위6.05화2.64，P치위0.02화0.01］；경다인소Logistic회귀모형분석，역제시저량개인소여정신분렬증적발병유관（고열량궐적OR=4.7，P=0.06，영유인기환엄중질병적OR=2.7，P=0.02）。（2）고열량궐、영유인기환엄중질병여PSST화/혹PSA고분수유일정관계。PSST급PSA적고분화중분자환정신분렬증적궤회교저분자증가（P<0.001）。결론고열량궐급영유인기환엄중질병가능증가정신분렬증적역감성，저량개인소가능여인동、청소년기적개성화사회괄응불량유관。
Objective　To study the relationship between neurodevelopment risk factors and the susceptibility of schizophrenia. Methods　Three hundred and ten schizophrenic patients and their 307 normal sibs coming from 166 families were studied. Univariable and multivariable logistic regression analyses were performed to explain the relationship between neurodevelopment risk factors and schizophrenia. Results　（1） Univariable and multivariable logistic regression analyses showed that febrile convulsion and severe somatic disease during early childhood were related to the susceptibility of schizophrenia. With univariable analysis, the correlation between febrile convulsion and schizophrenia showed OR=6.05, P=0.02, severe disease showed OR=2.64, P=0.01; With multivariable analysis, febrile convulsion showed OR=4.7, P=0.06, severe disease showed OR=2.7, P=0.02. （2） Febrile convulsion and severe disease were related to high scores of PSST and/or PSA. Comparing to the individuals with low scores of PSST and PSA, individuals with high and middle score showed higher risk of schizophrenia, P<0.001. Conclusion　Febrile convulsion and severe disease during early childhood may increase the susceptibility of schizophrenia. On the other hand, febrile convulsion and severe disease may be related to the personality traits and social adjustment disorders in childhood and early adolescent, and such disorders may be related to the susceptibility of schizophrenia.