外科研究与新技术
外科研究與新技術
외과연구여신기술
SURGICAL RESEARCH AND NEW TECHNIQUE
2012年
1期
13-18,65
,共7页
去甲斑蝥素%抗癌药物%凋亡%侵袭%血管生成%血管生成拟态
去甲斑蝥素%抗癌藥物%凋亡%侵襲%血管生成%血管生成擬態
거갑반모소%항암약물%조망%침습%혈관생성%혈관생성의태
Norcantharidin (NCTD)%Anticancer agent%Apoptosis%Invasion%Angiogenesis%Vasculogenic mimicry
去甲斑蝥素是传统抗癌中药斑蝥的活性成分斑蝥素的去甲基衍生物,近年在中国已作为一种常规的抗癌药物在临床应用.显然,了解去甲斑蝥素的抗癌作用及其分子机制有益于其临床应用和推广.但有关这方面的讨论文章却很少.本文将重点介绍去甲斑蝥素的抗癌作用,如诱导凋亡、抑制增殖、阻止侵袭转移、抗血管生成和/或抗血管生成拟态以及它们的分子机制.
去甲斑蝥素是傳統抗癌中藥斑蝥的活性成分斑蝥素的去甲基衍生物,近年在中國已作為一種常規的抗癌藥物在臨床應用.顯然,瞭解去甲斑蝥素的抗癌作用及其分子機製有益于其臨床應用和推廣.但有關這方麵的討論文章卻很少.本文將重點介紹去甲斑蝥素的抗癌作用,如誘導凋亡、抑製增殖、阻止侵襲轉移、抗血管生成和/或抗血管生成擬態以及它們的分子機製.
거갑반모소시전통항암중약반모적활성성분반모소적거갑기연생물,근년재중국이작위일충상규적항암약물재림상응용.현연,료해거갑반모소적항암작용급기분자궤제유익우기림상응용화추엄.단유관저방면적토논문장각흔소.본문장중점개소거갑반모소적항암작용,여유도조망、억제증식、조지침습전이、항혈관생성화/혹항혈관생성의태이급타문적분자궤제.
Norcantharidin (NCTD) is a demethylated derivative of cantharidin which is an anticancer active ingredient of traditional Chinese medicine,and currently used clinically as a routine anti-cancer drug in China.Distinctly,understanding the anticancer effects and molecular mechanisms of NCTD is an important key for NCTD that serves as an anticancer drug in clinic.But,NCTD's anticancer effects and mechanisms remain to be rarely elucidated.Here,we will review the key anticancer effects of NCTD,such as inducing cell apoptosis,inhibiting cell proliferation,blocking tumor invasion and metastasis,anti-angiogenesis and/or anti-vasculogenic mimicry,and their molecular mechanisms.
