CAJ | 학술논문

采用以琥珀酸酐和氯化亚砜活化的单甲氧基聚乙二醇,对白藜芦醇进行了化学修饰,以期改善其水溶性并增加其稳定性.通过官能团反应,白藜芦醇分子接上单甲氧基聚乙二醇分子,合成出一种枝化白藜芦醇单甲氧基聚乙二醇衍生物;对单甲氧基聚乙二醇端羟基依次进行羧基化、酰氟华等活化处理,通过酰氯与羟基的官能团反应合成出目标分子.应用透析方法分离纯化得到修饰产物,通过红外光谱分析、紫外光谱分析、HPLC分析,证实了产物与目标分子的结构相吻合.
채용이호박산항화록화아풍활화적단갑양기취을이순,대백려호순진행료화학수식,이기개선기수용성병증가기은정성.통과관능단반응,백려호순분자접상단갑양기취을이순분자,합성출일충지화백려호순단갑양기취을이순연생물;대단갑양기취을이순단간기의차진행최기화、선불화등활화처리,통과선록여간기적관능단반응합성출목표분자.응용투석방법분리순화득도수식산물,통과홍외광보분석、자외광보분석、HPLC분석,증실료산물여목표분자적결구상문합.
A kind of monomethoxypolyethylene glycol was used to modify resveratrol and the optimal modification factors were got.A novel type branched macromolecule was synthesized from the resveratrol and the monomethoxypoly(ethylene glycol,(mPEG).mPEG was activated by changing hydroxide teminal into acid chloride and carboxylation of mPEG was fulfilled before.The amino group was reserved so that it could be used as functional radical to modify resveratrol later.The mono-PEGylated product was isolated from the reaction mixture by the measure of dialyze.The PEGylated resveratrol showed better stability.and its dissolve trait was beaer enhanced.