中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
CHINESE JOURNAL OF MATERNAL AND CHILD HEALTH RESEARCH
2009年
4期
442-445
,共4页
左炔诺孕酮%药物释放系统%子宫内膜异位症%功能失调性子宫出血%避孕
左炔諾孕酮%藥物釋放繫統%子宮內膜異位癥%功能失調性子宮齣血%避孕
좌결낙잉동%약물석방계통%자궁내막이위증%공능실조성자궁출혈%피잉
levonorgestrel%drug releasing system%endometriosis(EMs)%dysfunctional uterine bleeding(DUB)%contraception
目的 探讨曼月乐的临床应用疗效.方法 对于健康妇女单纯要求避孕者81例,子宫腺肌症患者要求避孕及治疗者32例,子宫内膜异位症患者保守手术后要求尝试治疗者6例,月经过多的功能性子宫出血(经诊刮病理确诊)患者要求治疗者10例,适时宫内放置曼月乐,定期随访观察避孕效果、月经、痛经程度、子宫腺肌症患者子宫大小、功能性子宫出血患者子宫内膜厚度等变化.结果 曼月乐带器妊娠率为0,放置曼月乐12个月后,所有妇女的月经量为放置前的(8±3)%,子宫腺肌症患者血清CA125水平由72±50kU/L下降至31±24kU/L,治疗前后相比,差异有统计学意义(t=2.373,P<0.05);功能性子宫出血患者子宫内膜厚度由13.2±5.1mm变薄为5.9±1.9mm,治疗前后相比,差异有统计学意义(t=3.452,P<0.01);健康妇女及子宫腺肌症患者的痛经症状完全缓解,子宫内膜异位症患者的痛经有4例完全缓解或明显缓解,2例部分缓解.结论 曼月乐在避孕及子宫腺肌症、功能性子宫出血的治疗上均效果显著,对子宫内膜异位症的治疗有一定的疗效.
目的 探討曼月樂的臨床應用療效.方法 對于健康婦女單純要求避孕者81例,子宮腺肌癥患者要求避孕及治療者32例,子宮內膜異位癥患者保守手術後要求嘗試治療者6例,月經過多的功能性子宮齣血(經診颳病理確診)患者要求治療者10例,適時宮內放置曼月樂,定期隨訪觀察避孕效果、月經、痛經程度、子宮腺肌癥患者子宮大小、功能性子宮齣血患者子宮內膜厚度等變化.結果 曼月樂帶器妊娠率為0,放置曼月樂12箇月後,所有婦女的月經量為放置前的(8±3)%,子宮腺肌癥患者血清CA125水平由72±50kU/L下降至31±24kU/L,治療前後相比,差異有統計學意義(t=2.373,P<0.05);功能性子宮齣血患者子宮內膜厚度由13.2±5.1mm變薄為5.9±1.9mm,治療前後相比,差異有統計學意義(t=3.452,P<0.01);健康婦女及子宮腺肌癥患者的痛經癥狀完全緩解,子宮內膜異位癥患者的痛經有4例完全緩解或明顯緩解,2例部分緩解.結論 曼月樂在避孕及子宮腺肌癥、功能性子宮齣血的治療上均效果顯著,對子宮內膜異位癥的治療有一定的療效.
목적 탐토만월악적림상응용료효.방법 대우건강부녀단순요구피잉자81례,자궁선기증환자요구피잉급치료자32례,자궁내막이위증환자보수수술후요구상시치료자6례,월경과다적공능성자궁출혈(경진괄병리학진)환자요구치료자10례,괄시궁내방치만월악,정기수방관찰피잉효과、월경、통경정도、자궁선기증환자자궁대소、공능성자궁출혈환자자궁내막후도등변화.결과 만월악대기임신솔위0,방치만월악12개월후,소유부녀적월경량위방치전적(8±3)%,자궁선기증환자혈청CA125수평유72±50kU/L하강지31±24kU/L,치료전후상비,차이유통계학의의(t=2.373,P<0.05);공능성자궁출혈환자자궁내막후도유13.2±5.1mm변박위5.9±1.9mm,치료전후상비,차이유통계학의의(t=3.452,P<0.01);건강부녀급자궁선기증환자적통경증상완전완해,자궁내막이위증환자적통경유4례완전완해혹명현완해,2례부분완해.결론 만월악재피잉급자궁선기증、공능성자궁출혈적치료상균효과현저,대자궁내막이위증적치료유일정적료효.
Objective To observe clinical efficacy and safety of levonorgestrel-releasing intrauterine system (LNG-IUS). Methods 81 healthy women who only required contraception, 32 women with adenomyosis (AM) who required contraception and treatment, 6 women after conservative operation for endometriosis (EMs) who wanted an attempting treatment and 10 women with dysfunctional uterine bleeding (DUB) presenting menorrhagia (confirmed by diagnostic curettage and pathological examination) required treatment were inserted LNG-IUS into their uterine cavity timely and were regularily followed-up for contraceptive effect, menstruation, dysmenorrhea severity, size of uterine and endometrial thickness. Results The pregnancy rate in women carring LNG-IUS was 0. After 12 months treatment of LNG-IUS, the menstrual amounts of all women were reduced significantly to (8±3)% of that before treatment (P<0.01). The serum level of CA125 of the patients with AM dropped from 72±50kU/L to 31±24kU/L, and the difference was statistically significant (t=2.373,P<0.05). The endometrial thickness of patients with DUB was thinned from 13.2±5.1mm to 5.9±1.9mm, and the difference was statistically significant (t=3.452,P<0.01). The symptom dysmenorrhea of healthy women and patients with AM was completely remitted, while that of 4 patients with EMs was completely or remarkably remitted, and that of 2 patients with EMs was partly remitted. Conclusion LNG-IUS presents significant contraceptive effect and therapeutic effect for AM and DUB, also, it exerts certain therapeuitc effect for EMs.
