CAJ | 학술논문

用微量热法研究一种新型希夫碱及其3d,4f配合物(2L,2LZnYb)对大肠杆菌和金黄色葡萄球菌的抗菌活性,得到了在它们作用下大肠杆菌和金黄色葡萄球菌生长代谢的产热曲线,并且基于分析生长代谢和非生长代谢的产热曲线建立的热动力学方程,获得了它们的抗菌活性.结果表明,两种化合物(ZL,2LZnYb)对大肠杆菌的生长代谢有强的活性(IC5o分别为6.1和5.1 mg·L-1),但对金黄色葡萄球菌的生长代谢的活性弱得多(IC50分别为310.1和595.5 mg·L-1).Zn和Yb的导人使化合物对大肠杆菌生长代谢的抑制作用稍微增加,但大大降低了对金黄色葡萄球菌的抑制作用.对于非生长代谢,两种化合物的活性有很大的差别.无论对大肠杆菌还是金黄色葡萄球菌,由于配体2L的导入,表现出显著的抑制作用,2L的MSC50为6.4和209.7 mg·L-1.配体2L可能成为新的抗菌先导化合物.
용미량열법연구일충신형희부감급기3d,4f배합물(2L,2LZnYb)대대장간균화금황색포도구균적항균활성,득도료재타문작용하대장간균화금황색포도구균생장대사적산열곡선,병차기우분석생장대사화비생장대사적산열곡선건립적열동역학방정,획득료타문적항균활성.결과표명,량충화합물(ZL,2LZnYb)대대장간균적생장대사유강적활성(IC5o분별위6.1화5.1 mg·L-1),단대금황색포도구균적생장대사적활성약득다(IC50분별위310.1화595.5 mg·L-1).Zn화Yb적도인사화합물대대장간균생장대사적억제작용초미증가,단대대강저료대금황색포도구균적억제작용.대우비생장대사,량충화합물적활성유흔대적차별.무론대대장간균환시금황색포도구균,유우배체2L적도입,표현출현저적억제작용,2L적MSC50위6.4화209.7 mg·L-1.배체2L가능성위신적항균선도화합물.
The microcalorimetric method was used to study the antibacterial activity on the bacteria's multiplying metabolism and the non multiplying metabolism. The metabolism thermogenic curves ofEscherichia coli (E. coli) and Staphylococcus aureus (S. aureus), under the action of the synthesized Schiff base and its 3d, 4f complexes (2L,2LZnYb), were obtained. The results showed that the multiplying metabolism and the non multiplying metabolism of bacteria could be analyzed by the thermogenic curves using the thermokinetic equations. On the multiplying metabolism, the two compounds (ZL, 2LZnYb) have strong activity for E. coli. (IC50 (half-inhibitory respectively). The introduction of Zn and Yb with the compound slightly increased the inhibition on the multiplying metabolism of E. coli but greatly decreased the effect on that of S. aureus. The activity of these two compounds showed great difference on the non multiplying metabolism. Regardless of E. coli or S. aureus, 2L just showed a two microorganisms, respectively. Thus, 2L may become a novel kind of potential antibacterial candidate.