CAJ | 학술논문

背景:亚低温在脑梗死的治疗中已经得到广泛应用,实施体表亚低温是否会影响血压,此影响有利还是有弊,需要进一步研究考证.目的:观察亚低温治疗实验性脑梗死大鼠血压的变化,进一步探讨其对脑保护功能的影响.设计:随机对照实验.单位:武汉大学人民医院神经内科.材料:实验在武汉大学人民医院神经内科实验室进行.选择SD大鼠120只,随机分为对照组和实验组,每组60只.方法:实验组在大脑中动脉闭塞后3 h将动物置于4℃环境中,使肛温控制在(34±1.0)℃;对照组置于室温(20℃)环境中.所有动物在大脑中动脉阻塞后2 h开始再灌注.用监护仪监测心率、呼吸、血氧饱和度、肛温和血压.24 h后麻醉下处死动物,取脑组织作梗死灶总体积测定.主要观察指标:①两组大鼠实验前后心率、呼吸、血氧饱和度、平均动脉血和血压变化.②两组大鼠梗死灶体积.结果:①两组阻塞后的血压均较阻塞前明显升高[(150±7.2),(129±5.7)mm Hg;(149±7.5),(130±2.2)mm Hg,P＜0.01],两组比较差异无显著性意义(P＞0.05).开始亚低温后,亚低温组的血压明显降低(P＜0.04).②亚低温组的脑梗死体积明显小于对照组[(153.17±26.83)mm3对(251.45±36.70)mm3,P＜0.01].结论:亚低温在缩小脑梗死体积的同时,能引起血压明显降低.
배경:아저온재뇌경사적치료중이경득도엄범응용,실시체표아저온시부회영향혈압,차영향유리환시유폐,수요진일보연구고증.목적:관찰아저온치료실험성뇌경사대서혈압적변화,진일보탐토기대뇌보호공능적영향.설계:수궤대조실험.단위:무한대학인민의원신경내과.재료:실험재무한대학인민의원신경내과실험실진행.선택SD대서120지,수궤분위대조조화실험조,매조60지.방법:실험조재대뇌중동맥폐새후3 h장동물치우4℃배경중,사항온공제재(34±1.0)℃;대조조치우실온(20℃)배경중.소유동물재대뇌중동맥조새후2 h개시재관주.용감호의감측심솔、호흡、혈양포화도、항온화혈압.24 h후마취하처사동물,취뇌조직작경사조총체적측정.주요관찰지표:①량조대서실험전후심솔、호흡、혈양포화도、평균동맥혈화혈압변화.②량조대서경사조체적.결과:①량조조새후적혈압균교조새전명현승고[(150±7.2),(129±5.7)mm Hg;(149±7.5),(130±2.2)mm Hg,P＜0.01],량조비교차이무현저성의의(P＞0.05).개시아저온후,아저온조적혈압명현강저(P＜0.04).②아저온조적뇌경사체적명현소우대조조[(153.17±26.83)mm3대(251.45±36.70)mm3,P＜0.01].결론:아저온재축소뇌경사체적적동시,능인기혈압명현강저.
BACKGROUND: Sub-hypothermia has been widely used to treat cerebral infarction. Whether sub-hypothermia treated on body surface affects blood pressure or not, or the effect is advantageous or disadvantageous should be researched further.OBJECTIVE: To observe the effect of sub-hypothermia on blood pressure of rats with experimental cerebral infarction so as to investigate its influence on cerebral protective function.DESIGN: Randomized controlled study.SETTING: Neurological Department of Renmin Hospital of Wuhan University.MATERIALS: The experiment was completed in the Neurological Laboratory of Renmin Hospital of Wuhan University. Totally 120 SD rats were selected and divided randomly into control group and experimental group with 60 in each group.METHODS: Rats in experimental group were maintained at 4 ℃ 3 hours after MCA obstruction, and rectal temperature was maintained at (34±1.0) ℃;rats in control group were maintained at room temperature (20 ℃). All animals were reperfused 2 hours after MCA obstruction. Heart rate,breath, blood oxygen saturation, anus temperature and blood pressure were assayed with monitor. Rats were sacrificed under anesthesia after 24 hours, and cerebral tissue was taken out to measure the total volume of infarct focus.MAIN OUTCOME MEASURES: ① Changes of heart rate, breath,blood oxygen saturation, · mean arterial blood and blood pressure of rats in the two groups before and after treatment; ② volume of infarct focus of rats in the two groups.RESULTS: ① Values of blood pressure in both groups were increased after obstruction as compared with those before obstruction [(150±7.2),(129±5.7) mm Hg; (149±7.5), (130±2.2) mm Hg, P ＜ 0. 01], and there was not significant difference (P ＞ 0.05). Blood pressure was decreased obviously in sub-hypothermia group at the beginning of sub-hypothermia (P＜ 0.01). ② Volume of cerebral infarction was obviously smaller in subhypothermia group than that in control group [(153.17±26.83) mm3,(251.45±36.70) mm3, P ＜ 0.01].CONCLUSION: Sub-hypothermia can both reduce the volume of cerebral infarction and decrease the blood pressure obviously.