CAJ | 학술논문

目的：观察立复汀喷雾剂治疗小儿变应性鼻炎的效果，并探讨其机制。方法：对113例小儿变应性鼻炎患者，分别用立复汀喷雾剂(立复汀组)和生理盐水喷鼻剂(生理盐水组)进行治疗和疗效对比。结果：立复汀组的总有效率为95.1％，生理盐水组为25.0％；立复汀组起效时间72.1％在1 min以内，维持时间72.1％在5 h以上；而生理盐水组起效时间23.1％在3 min以内，维持时间30.8％在3 h以内。2周后，立复汀组所查鼻分泌物中嗜酸性粒细胞明显减少或消失(P＜0.05)。结论：立复汀喷雾剂缓解症状迅速，维持时间长，疗效显著，安全性好，是治疗小儿变应性鼻炎的有效药物。
목적：관찰립복정분무제치료소인변응성비염적효과，병탐토기궤제。방법：대113례소인변응성비염환자，분별용립복정분무제(립복정조)화생리염수분비제(생리염수조)진행치료화료효대비。결과：립복정조적총유효솔위95.1％，생리염수조위25.0％；립복정조기효시간72.1％재1 min이내，유지시간72.1％재5 h이상；이생리염수조기효시간23.1％재3 min이내，유지시간30.8％재3 h이내。2주후，립복정조소사비분비물중기산성립세포명현감소혹소실(P＜0.05)。결론：립복정분무제완해증상신속，유지시간장，료효현저，안전성호，시치료소인변응성비염적유효약물。
Objective:To observe the effect of Livostin spray on children＇s allergic rhinitis and to search the mechanism of treating allergic rhinitis. Method: 113 patients were treated with Livostin spray (Livostin group) or normal saline spray (control group). Result:The total efficiency of Livostin group in treating allergic rhinitis is above 95.1％ and that of the control group is 25.0％. Initial time of starting effect of Livostin (72.1％) is in 1 minute, and that of the control group (mostly 23.1％) is in 3 minutes. The keeping curativeeffect time of Livostin spray is mostly (72.1％) above 5 hours and that of the control group is mostly (30.8％) in 3 hours. After 2 weeks,the eosinophilic granulocyte number in nose＇s secretion of Livostin group is obviously reduced (P＜0.05). Conclusion: Livostin is better than control group in relieving symptoms, keeping curative effect and safety,so Livostin is one kind of effective drug in treating children＇s allergic rhinitis.