CAJ | 학술논문

为探讨C-反应蛋白与动脉粥样硬化及其它心血管病危险因素的关系，以高分辨率B型超声法测定91例受检者的颈动脉内膜-中膜厚度，作为动脉粥样硬化的指标；以生物化学方法测定血清C-反应蛋白、血脂水平和血浆凝血纤溶活性。结果发现，颈动脉内膜-中膜厚度≥0.8 mm组的血清C-反应蛋白水平高于内膜-中膜厚度<0.8 mm组（4.4±4.3 mg/L比2.7±1.3 mg/L），但差异的显著性无统计学意义（P=0.071）。6例血清C-反应蛋白水平≥8.0 mg/L者颈动脉内膜-中膜厚度明显高于其余85例血清C-反应蛋白<8.0 mg/L者（1.033±0.294 mm比0.812±0.222 mm， P<0.05）。多因素逐步回归分析显示血清C-反应蛋白水平与血清甘油三酯水平(β=0.533， P=0.002)，及血浆凝血因子VII (β=0.406， P=0.017)和纤溶酶原激活物抑制剂-1 (β=0.312，P=0.05)活性呈显著正相关。因此，C-反应蛋白作为某些炎症的反应蛋白，与颈动脉内膜-中膜厚度及其某些心血管病危险因素有关，提示炎症因素可能在动脉粥样硬化发病中起作用。
위탐토C-반응단백여동맥죽양경화급기타심혈관병위험인소적관계，이고분변솔B형초성법측정91례수검자적경동맥내막-중막후도，작위동맥죽양경화적지표；이생물화학방법측정혈청C-반응단백、혈지수평화혈장응혈섬용활성。결과발현，경동맥내막-중막후도≥0.8 mm조적혈청C-반응단백수평고우내막-중막후도<0.8 mm조（4.4±4.3 mg/L비2.7±1.3 mg/L），단차이적현저성무통계학의의（P=0.071）。6례혈청C-반응단백수평≥8.0 mg/L자경동맥내막-중막후도명현고우기여85례혈청C-반응단백<8.0 mg/L자（1.033±0.294 mm비0.812±0.222 mm， P<0.05）。다인소축보회귀분석현시혈청C-반응단백수평여혈청감유삼지수평(β=0.533， P=0.002)，급혈장응혈인자VII (β=0.406， P=0.017)화섬용매원격활물억제제-1 (β=0.312，P=0.05)활성정현저정상관。인차，C-반응단백작위모사염증적반응단백，여경동맥내막-중막후도급기모사심혈관병위험인소유관，제시염증인소가능재동맥죽양경화발병중기작용。
Aim　To investigate the association of C-reactive protein (CRP) with carotid intima-media thickness and some risk factors of cardiovascular disease.　Methods　Carotid IMT was measured by high resolution B-mode ultrasound, and blood levels of CRP, lipids, clotting factors and fibrinolytic parameters were determined by relevant biochemical assay in 91 subjects.　Results　The difference in level of CRP between subjects with carotid IMT≥0.8 mm and those with IMT <0.8 mm was not significant (4.4±4.3 mg/L vs 2.7±1.3 mg/L, P=0.07), while the IMT was significantly higher in 6 subjects with CRP≥8.0 mg/L than those with CRP<8.0 mg/L (1.033±0.294 mm vs 0.812±0.222 mm, P<0.05).　The level of CRP was positively correlated with triglyceride level, activities of coagulating factor VII and plasminogen activator inhibitor type-1 on multiple stepwise regression analysis.　Conclusion　Higher level of CRP, the reactant of inflammation, may account for the role of inflammation in the pathogenesis of atherosclerosis.