中国新药杂志
中國新藥雜誌
중국신약잡지
CHINESE NEW DRUGS JOURNAL
2001年
3期
198-200
,共3页
ZHANG Jian-chun%张建春%邓明德%陈鼎继%蒋雪涛
ZHANG Jian-chun%張建春%鄧明德%陳鼎繼%蔣雪濤
ZHANG Jian-chun%장건춘%산명덕%진정계%장설도
法莫替丁%口溶片%高效液相色谱法%生物利用度%药代动力学
法莫替丁%口溶片%高效液相色譜法%生物利用度%藥代動力學
법막체정%구용편%고효액상색보법%생물이용도%약대동역학
目的：研究法莫替丁口溶片在家兔体内的药代动力学过程和生物利用度。方法：家兔单剂量服用法莫替丁口溶片和法莫替丁普通市售片后，用高效液相色谱法测定血药浓度。结果:法莫替丁口溶片和普通市售片的AUC分别为(2 687.63±461.65)和(1 477.65±484.28)(ng*h)/ml,C max为(658.18±84.97) 和(202.80±57.29) ng/ml,Tmax为(1.29±0.23)和(2.85 ±0.54)h。结论:口溶片与普通片AUC的差异有统计学意义(P<0.0 1),相对生物利用度为181.88%。
目的：研究法莫替丁口溶片在傢兔體內的藥代動力學過程和生物利用度。方法：傢兔單劑量服用法莫替丁口溶片和法莫替丁普通市售片後，用高效液相色譜法測定血藥濃度。結果:法莫替丁口溶片和普通市售片的AUC分彆為(2 687.63±461.65)和(1 477.65±484.28)(ng*h)/ml,C max為(658.18±84.97) 和(202.80±57.29) ng/ml,Tmax為(1.29±0.23)和(2.85 ±0.54)h。結論:口溶片與普通片AUC的差異有統計學意義(P<0.0 1),相對生物利用度為181.88%。
목적：연구법막체정구용편재가토체내적약대동역학과정화생물이용도。방법：가토단제량복용법막체정구용편화법막체정보통시수편후，용고효액상색보법측정혈약농도。결과:법막체정구용편화보통시수편적AUC분별위(2 687.63±461.65)화(1 477.65±484.28)(ng*h)/ml,C max위(658.18±84.97) 화(202.80±57.29) ng/ml,Tmax위(1.29±0.23)화(2.85 ±0.54)h。결론:구용편여보통편AUC적차이유통계학의의(P<0.0 1),상대생물이용도위181.88%。
Objective:To study the pharmacokinetics and bioavai lability of rapid dissolving tablet of famotidine in mouth and famotidine market tablet in rabbits.Methods:Rapid dissolving tablets in mouth and m arket tablets of famotidine were single-dose orally given to rabbits.The blood levels of famotidine was determined by HPLC method.Results:The AUC ,Cmax and Tmax of rapid dissolving tablets in mouth of famotidine we re (2 687.63±461.65)(ng*h)/ml,(658.18±84.97)ng/ml and (1.29±0.23)h,and t he AUC,Cmax and Tmax of market tablet of famotidine were (1 4 77.65±484.28)(ng*h)/ml,(202.80±57.29) ng/ml and (2.85±0.54)h. Conclusion:There is significant difference (P<0.01) between the AUC of two products,and the bioavailability of rapid dissolving tablet of famot idine in mouth is 181.88%.
