CAJ | 학술논문

目的：了解卵巢癌中谷胱甘肽S-转移酶-π(GST-π)的表达与化疗的关系。方法：运用免疫组织化学技术对74例术前未治疗的上皮性卵巢癌进行GST-π检测。结果：74例卵巢癌中GST-π阳性55例，阳性率为74.3%。卵巢癌中GST-π的表达与病理类型无相关性(P＞0.05)。对首次术后有残余癌的27例患者行化疗反应评价，GST-π阳性者与阴性者的化疗反应率为13.3%及83.3%，两者间差异有显著性(P＜0.01)。GST-π阳性对耐药的预测值为86.7%，GST-π阴性对化疗反应的预测值为83.3%。结论：未治疗卵巢癌中存在着由GST-π介导的内在性耐药机制，GST-π的表达能较好地预测化疗反应。
목적：료해란소암중곡광감태S-전이매-π(GST-π)적표체여화료적관계。방법：운용면역조직화학기술대74례술전미치료적상피성란소암진행GST-π검측。결과：74례란소암중GST-π양성55례，양성솔위74.3%。란소암중GST-π적표체여병리류형무상관성(P＞0.05)。대수차술후유잔여암적27례환자행화료반응평개，GST-π양성자여음성자적화료반응솔위13.3%급83.3%，량자간차이유현저성(P＜0.01)。GST-π양성대내약적예측치위86.7%，GST-π음성대화료반응적예측치위83.3%。결론：미치료란소암중존재착유GST-π개도적내재성내약궤제，GST-π적표체능교호지예측화료반응。
To determine the relationship between the expression of glutathione S-transferase-π (GST-π) and the response to chemotherapy in ovarian cancer.Methods:Expression of GST-π was immunohistochemically studied in paraffin sections from 74 patients with ovarian cancer who had not received any chemotherapy before surgery.Results:GST-π immunoreactivity was present in 55 (74.3%) of the tumor tissues and was not associated with histopathologic types.Of 27 clinically measurable lesions after surgery,the response rate to chemotherapy in GST-π-positive group (13.3,2/15) was significantly lower than that in the GST-π-negative group (83.3,10/12;P＜0.01).The predictive value of positive GST-π staining for drug resistance was 86.7%,and that of negative staining for objective responders was 83.3%.Conclusion:The data suggest that GST-π expression in tumor cells is related to drug resistance of the patients with epithelial ovarian cancer and is a useful marker of response to chemotherapy.