CAJ | 학술논문

躯体和心理应激均能在HPG轴多水平抑制或损害生殖内分泌功能尤其是女性生殖内分泌功能，从而导致人类亚健康状态、临床生殖内分泌系统疾病，其发生机制与应激引起的下丘脑CRF和肾上腺GCS过度释放及其它神经内分泌改变密切相关，而生殖内分泌激素合成酶活性的应激性降低则为性激素降低和生殖内分泌系统功能紊乱的直接原因。
구체화심리응격균능재HPG축다수평억제혹손해생식내분비공능우기시녀성생식내분비공능，종이도치인류아건강상태、림상생식내분비계통질병，기발생궤제여응격인기적하구뇌CRF화신상선GCS과도석방급기타신경내분비개변밀절상관，이생식내분비격소합성매활성적응격성강저칙위성격소강저화생식내분비계통공능문란적직접원인。
Physical and psychological stresses inhibit or harm reproductive endocrine especially female one at many levels of hypothalamo-pituitary-gonadal (HPG) axis, and result in subhealth conditions or clinic diseases in reproductive endocrine. The hypothalamic corticotropin-releasing factor (CRF) and adrenal glucocorticoids (GCS) overreleases and other neuroendocrine alterations induced by stress are implicated in the mechanisms responsible for the disturbance of reproductive endocrine. The declines in activities of synzyms for reproductive hormones cause sexual hormones reduces and disfunction in reproductive endocrine system.