CAJ | 학술논문

目的　在地塞米松磷酸钠诱导下建立大鼠卡氏肺孢子虫肺炎的动物模型。方法　将40只雌性SD大鼠随机分为实验组和对照组,前者皮下注射地塞米松磷酸钠，1 mg/次，2次/w；后者不做任何处理。观察两组大鼠的发病情况，并每隔3周两组各取5只动物进行病原学检查。结果　实验组大鼠第6周开始发病，肺印片、支气管肺泡灌洗液沉渣中查到卡氏肺孢子虫包囊及滋养体;对照组大鼠无异常表现，病原学检查阴性。结论　在地塞米松磷酸钠诱导下可成功建立大鼠卡氏肺孢子虫肺炎动物模型。
목적　재지새미송린산납유도하건립대서잡씨폐포자충폐염적동물모형。방법　장40지자성SD대서수궤분위실험조화대조조,전자피하주사지새미송린산납，1 mg/차，2차/w；후자불주임하처리。관찰량조대서적발병정황，병매격3주량조각취5지동물진행병원학검사。결과　실험조대서제6주개시발병，폐인편、지기관폐포관세액침사중사도잡씨폐포자충포낭급자양체;대조조대서무이상표현，병원학검사음성。결론　재지새미송린산납유도하가성공건립대서잡씨폐포자충폐염동물모형。
Objective　To explore the possibility for the induction of pneumocystis carinii pneumonia(PCP) in rats by dexamethasone.Methods　Forty female SD rats were randomly divided into experimental group（n=20）and control group（n=20）.Experimental group was injected subcutaneously with dexamethasone twice a week and control group was not processed.The pathogen and condition of infection were examined at 3 weeks interval. Results　Experimental group appeared clinical syndromes.The peumocystis carinii cysts and trophozoites had been found in the lung imprints and precipitate of bronchoalveolar lavage fluid since the 6th week,while no peumocystis carinii cysts and trophozoites could be found in the lung imprints and bronchoalveolar lavage fluid of control group.Conclusion　PCP rat model was successfully established by inducement of dexamethasone.