合成化学
閤成化學
합성화학
CHINESE JOURNAL OF SYNTHETIC CHEMISTRY
2003年
2期
150-152
,共3页
贾义霞%高建荣%盛卫坚%俞开新
賈義霞%高建榮%盛衛堅%俞開新
가의하%고건영%성위견%유개신
δ-戊内酯%环己胺%叠氮化钠%血小板阻聚物%四氮唑%中间体%相转移催化
δ-戊內酯%環己胺%疊氮化鈉%血小闆阻聚物%四氮唑%中間體%相轉移催化
δ-무내지%배기알%첩담화납%혈소판조취물%사담서%중간체%상전이최화
δ-valerolactone%intermediate%tetrazole%cyclohexylamine%platelet aggregation inhibitor drug%synthesis
以δ-戊内酯和环己胺为原料合成了抗血小板聚集药物西洛他唑的重要中间体N-环己基-5-氯丁基-1H-四氮唑,选择了合适的相转移催化剂及安全的叠氮试剂并获得较高的收率.
以δ-戊內酯和環己胺為原料閤成瞭抗血小闆聚集藥物西洛他唑的重要中間體N-環己基-5-氯丁基-1H-四氮唑,選擇瞭閤適的相轉移催化劑及安全的疊氮試劑併穫得較高的收率.
이δ-무내지화배기알위원료합성료항혈소판취집약물서락타서적중요중간체N-배기기-5-록정기-1H-사담서,선택료합괄적상전이최화제급안전적첩담시제병획득교고적수솔.
N-cyclohexyl-5-(4'-chlorobutyl)-1H-tetrazole was synthesized by a convenient process fromδ-valerolactone and cyclohexylamine. Appropriate cyclocondensation reagent and phase transfer catalyst were selected. The yield of product is 78%. The product is an important intermediate for producing drugs of blood platelets aggregation inhibitors.
