CAJ | 학술논문

目的观察西比灵对偏头痛的药物疗效。方法应用西比灵5～10ml，每晚睡前一次口服，一个月为一个疗程，疗程开始前两周和疗程结束后两周对比观察疗效。结果总有效率达91.1%，与对照组相比差异显著(P<0.01)，无不良反应。结论西比灵为选择性钙拮抗剂，可阻滞过量的钙离子跨膜进入细胞内，防止细胞内钙超载造成损伤。西比灵为治疗偏头痛的首选药物。
목적관찰서비령대편두통적약물료효。방법응용서비령5～10ml，매만수전일차구복，일개월위일개료정，료정개시전량주화료정결속후량주대비관찰료효。결과총유효솔체91.1%，여대조조상비차이현저(P<0.01)，무불량반응。결론서비령위선택성개길항제，가조체과량적개리자과막진입세포내，방지세포내개초재조성손상。서비령위치료편두통적수선약물。
Objective　 To study the effect of Sibeline in the treatment of migraine.Methods　 5～10 ml Sibeline was taken orally once before sleeping every night,one month as a course of treatment,the effects were compared two weeks before and after the course.Results　 The total response rate was 91.1%,there was obvious difference compared with the control group (P<0.01) without side effect. Conclusion　 Sibeline is selective calcium agonist,which can block too much calcium entering cells through the membrane,prevent too much calcium in cells causing injury.Sibeline is the first choice to treat migraine.