CAJ | 학술논문

基因治疗是一种带有生物学标志的靶向治疗,可以作为难治复发性血液系统恶性肿瘤的另一种选择.合理的选择病毒载体是治疗的关键,现就载体的特性、基因插入突变、机体的免疫屏障、提高载体的靶向性、转基因的维持和表达几个方面的研究进展作一综述.
기인치료시일충대유생물학표지적파향치료,가이작위난치복발성혈액계통악성종류적령일충선택.합리적선택병독재체시치료적관건,현취재체적특성、기인삽입돌변、궤체적면역병장、제고재체적파향성、전기인적유지화표체궤개방면적연구진전작일종술.
Gene therapy,a target therapy with biological markers,can be used as an alternative choice for refractory and relapsed hematologic malignancies. Reasonable choice of viral vectors is the key to treatment.This article will be reviewed on five aspects,which are the characteristics of the carrier,gene insertion mutation,the immune barrier,improvement the targeting of the vector and maintenance and expression of the transgene.