CAJ | 학술논문

目的了解上海地区在校中学生接种甲型H1N1流感疫苗前后的抗体水平,观察甲型H1N1流感疫苗对该人群的免疫保护作用.方法应用常规微量血凝抑制试验(micro-hemagglutination inhibition test,HIT)对上海地区在校中学生分3个时间段进行甲型H1N1流感病毒抗体的血清学监测,3个时间段的抗体阳性率比较采用Pearson x2检验进行分析.结果 2009年甲型H1N1流感流行前上海地区在校中学生的血清抗体阳性率仅为1.3%.经过一段时间流行后,血清抗体阳性率升至8.5%.接种甲型H1N1流感疫苗后,血清抗体阳性率升至87.3%.经Pearson x2检验分析,3个时间段在校中学生的血清甲型H1N1流感抗体阳性率差异有统计学意义(x2=243.7,P＜0.05).结论在甲型H1N1流感流行前,上海地区在校中学生对其几乎没有免疫力,接种甲型H1N1流感疫苗能为该人群提供较好的免疫保护作用.
목적 료해상해지구재교중학생접충갑형H1N1류감역묘전후적항체수평,관찰갑형H1N1류감역묘대해인군적면역보호작용.방법 응용상규미량혈응억제시험(micro-hemagglutination inhibition test,HIT)대상해지구재교중학생분3개시간단진행갑형H1N1류감병독항체적혈청학감측,3개시간단적항체양성솔비교채용Pearson x2검험진행분석.결과 2009년갑형H1N1류감류행전상해지구재교중학생적혈청항체양성솔부위1.3%.경과일단시간류행후,혈청항체양성솔승지8.5%.접충갑형H1N1류감역묘후,혈청항체양성솔승지87.3%.경Pearson x2검험분석,3개시간단재교중학생적혈청갑형H1N1류감항체양성솔차이유통계학의의(x2=243.7,P＜0.05).결론 재갑형H1N1류감류행전,상해지구재교중학생대기궤호몰유면역력,접충갑형H1N1류감역묘능위해인군제공교호적면역보호작용.
Objective To understand the levels of antibody to pandemic influenza A(H1N1)2009 virus before and after vaccination with pandemic influenza A(H1N1)2009 vaccines in Shanghai middle school students, and to observe the protection of pandemic influenza A(H1N1)2009 vaccines for this group.Methods The levels of antibody to pandemic influenza A(H1N1)2009 virus in Shanghai middle school students were determined using the routine micro-hemagglutination inhibition test in three periods, and the positive rates of the antibodies in three periods were compared by Pearson's x2 test. Results Before the epidemic of pandemic influenza A(H1N1)2009, the positive rate of antibody to pandemic influenza A (H1N1)2009 virus among Shanghai middle school students was only 1.3%, and then it increased to 8.5% after a period of epidemic. After vaccination with pandemic influenza A(H1N1)2009 vaccines, the positive rate of antibody to pandemic influenza A(H1N1)2009 virus among middle school students increased to 87.3%. The result of Pearson' sx2 test showed that differences of the positive rate of antibody in three periods had statistical significance(x2 = 243.7, P ＜ 0. 05). Conclusions Before the epidemic of pandemic influenza A(H1N1)2009, Shanghai middle school students almost have no immunity against this new type of virus, and vaccination with pandemic irfluenza A(H1N1)2009 vaccines can provide stronger protection for this group.