CAJ | 학술논문

目的探讨冠心病患者血清D-二聚体(D-D)和纤维蛋白原(Fg)检测的意义.方法 150例冠心病患者随机分为不稳定型心绞痛组(UA组)、稳定型心绞痛组(SA组)和急性心肌梗死组(AMI组)各50例,采用ELASA双抗夹心法检测D-D水平,CLAUSE法检测Fg水平.结果 SA组D-D水平与UA组、AMI组差异均有统计学意义(t=9.340、18.334,均P＜0.01);UA组D-D水平与AMI组差异有统计学意义(t=10.240,P＜0.01).SA组Fg水平与UA组、AMI组差异均有统计学意义(t=11.376、11.730,均P＜0.01);UA组Fg水平与AMI组差异有统计学意义(t=3.121,P＜0.01).D-D水平:单支病变组与双支病变组、三支病变组差异均有统计学意义(t=7.017、15.603,均P＜0.01);双支病变组与三支病变组差异有统计学意义(t =8.662,P＜0.01).Fg水平:单支病变组与双支病变组、三支病变组差异均有统计学意义(t=8.687、11.855,均P＜0.01);双支病变组与三支病变组差异有统计学意义(t=4.379,P＜0.01).结论不同类型冠心病患者血清D-D、Fg水平有较大差异,且冠状动脉病变越严重,D-D和Fg水平越高.
목적 탐토관심병환자혈청D-이취체(D-D)화섬유단백원(Fg)검측적의의.방법 150례관심병환자수궤분위불은정형심교통조(UA조)、은정형심교통조(SA조)화급성심기경사조(AMI조)각50례,채용ELASA쌍항협심법검측D-D수평,CLAUSE법검측Fg수평.결과 SA조D-D수평여UA조、AMI조차이균유통계학의의(t=9.340、18.334,균P＜0.01);UA조D-D수평여AMI조차이유통계학의의(t=10.240,P＜0.01).SA조Fg수평여UA조、AMI조차이균유통계학의의(t=11.376、11.730,균P＜0.01);UA조Fg수평여AMI조차이유통계학의의(t=3.121,P＜0.01).D-D수평:단지병변조여쌍지병변조、삼지병변조차이균유통계학의의(t=7.017、15.603,균P＜0.01);쌍지병변조여삼지병변조차이유통계학의의(t =8.662,P＜0.01).Fg수평:단지병변조여쌍지병변조、삼지병변조차이균유통계학의의(t=8.687、11.855,균P＜0.01);쌍지병변조여삼지병변조차이유통계학의의(t=4.379,P＜0.01).결론 불동류형관심병환자혈청D-D、Fg수평유교대차이,차관상동맥병변월엄중,D-D화Fg수평월고.
Objective To explore the detection meaning of D-dimer(D-D) and fibrinogen(Fg) in patients with coronary disease.Methods 150 patients with coronary disease were randomly divided into UA group,SA group and AMI group,the D-D was detected by ELASA double resistance to clip method and Fg was detected by CLIUSE methods.Results The D-D in SA group,UA group and AMI group showed significant difference between two groups (SA:UA,t =9.340;SA:AMI,t =18.334; UA:AMI,t =10.240.all P ＜0.01 ).The Fg in SA group,UA group and AMI group showed significant difference between each two groups ( SA:UA,t =11.376; SA:AMI,t =11.730; UA:AMI,t =3.121.all P ＜0.01 ).D-D between one coronary artery disease and two coronaries artery disease,three coronary arteries disease showed significant difference( t =7.017,15.603,all P ＜ 0.01 ) ; and between two coronaries artery disease and three coronary arteries disease showed significant difference,too ( t =8.662,P ＜ 0.01 ).The Fg between one coronary artery disease and two coronaries artery disease,three coronary arteries disease,showed significant difference( t =8.687,11.855,all P ＜ 0.01 ) ; and between two coronaries artery disease and three coronary arteries disease showed significant difference,too( t =4.379,P ＜ 0.0 1 ).Conclusion The D-D and Fg showed obvious difference between different types of coronary disease,and the levels increase along with the disease degrees of coronaries