中国医药
中國醫藥
중국의약
CHINA MEDICINE
2012年
11期
1357-1358
,共2页
高血压病%25-羟基维生素D3%甲状旁腺激素
高血壓病%25-羥基維生素D3%甲狀徬腺激素
고혈압병%25-간기유생소D3%갑상방선격소
Hypertension%25-hydroxyvitamin D3%Parathyroid hormone
目的 了解原发性高血压患者血清维生素D的变化,并探讨维生素D对原发性高血压发展的影响.方法 按危险因素将140例原发性高血压患者分为低危组(1级高血压且无其他危险因素,56例)、中危组(2级高血压或1级高血压伴1～2个危险因素,53例)和高危组(3级高血压或1～2级高血压伴≥3个危险因素或任何一级高血压伴1项靶器官损害或1种临床疾患,31例),并设立对照组(体检健康者,33例),检测4组的血清钙、磷、25-羟基维生素D3[25(OH)D3]、甲状旁腺激素(PTH).结果 低危、中危、高危组25(OH)D3分别为(27±6)、(27±5)、(21±5)μg/L,对照组为(32±8)μg/L,低危组与中危组之间差异无统计学意义(P＞0.05),其余各组之间差异有统计学意义(P＜0.05).25(OH)D3与收缩压、舒张压存在负相关(r值分别为-0.412、-0.377,均P＜0.01),与PTH、钙、磷、年龄无明显相关性.结论 原发性高血压患者血清维生素D水平降低,尤其是伴有高危因素的患者血清维生素D水平降低更明显.
目的 瞭解原髮性高血壓患者血清維生素D的變化,併探討維生素D對原髮性高血壓髮展的影響.方法 按危險因素將140例原髮性高血壓患者分為低危組(1級高血壓且無其他危險因素,56例)、中危組(2級高血壓或1級高血壓伴1～2箇危險因素,53例)和高危組(3級高血壓或1～2級高血壓伴≥3箇危險因素或任何一級高血壓伴1項靶器官損害或1種臨床疾患,31例),併設立對照組(體檢健康者,33例),檢測4組的血清鈣、燐、25-羥基維生素D3[25(OH)D3]、甲狀徬腺激素(PTH).結果 低危、中危、高危組25(OH)D3分彆為(27±6)、(27±5)、(21±5)μg/L,對照組為(32±8)μg/L,低危組與中危組之間差異無統計學意義(P＞0.05),其餘各組之間差異有統計學意義(P＜0.05).25(OH)D3與收縮壓、舒張壓存在負相關(r值分彆為-0.412、-0.377,均P＜0.01),與PTH、鈣、燐、年齡無明顯相關性.結論 原髮性高血壓患者血清維生素D水平降低,尤其是伴有高危因素的患者血清維生素D水平降低更明顯.
목적 료해원발성고혈압환자혈청유생소D적변화,병탐토유생소D대원발성고혈압발전적영향.방법 안위험인소장140례원발성고혈압환자분위저위조(1급고혈압차무기타위험인소,56례)、중위조(2급고혈압혹1급고혈압반1～2개위험인소,53례)화고위조(3급고혈압혹1～2급고혈압반≥3개위험인소혹임하일급고혈압반1항파기관손해혹1충림상질환,31례),병설립대조조(체검건강자,33례),검측4조적혈청개、린、25-간기유생소D3[25(OH)D3]、갑상방선격소(PTH).결과 저위、중위、고위조25(OH)D3분별위(27±6)、(27±5)、(21±5)μg/L,대조조위(32±8)μg/L,저위조여중위조지간차이무통계학의의(P＞0.05),기여각조지간차이유통계학의의(P＜0.05).25(OH)D3여수축압、서장압존재부상관(r치분별위-0.412、-0.377,균P＜0.01),여PTH、개、린、년령무명현상관성.결론 원발성고혈압환자혈청유생소D수평강저,우기시반유고위인소적환자혈청유생소D수평강저경명현.
Objective To investigate the changes of serum vitamin D levels in primary hypertension patients.Methods According to risk factors,56 patients were selected as low risk group; 53 patients were selected as intermediate risk group; 31 patients were selected as high risk group and 33 healthy subjects were selected as normal control group.The 25-hydroxyvitamin D3 was measured with enzyme-linked immunoassay(ELISA).The statistical data was analyzed by SPSS 18.0 software.Results The sex and age of four groups objects were not significantly different.The 25 (OH) D3 of low risk group was (27 ± 6)μg/L; the 25 (OH) D3 of intermediate risk group was (27 ± 5) μg/L.The 25 (OH) D3 of high risk group was (21± 5)μg/L.The 25 (OH) D3 of the healthy subjects was (32 ± 8) μg/L.The 25 (OH) D3 of low risk and high risk and the healthy groups objects were significantly different (P＜0.05).With simple regression analysis,the 25 (OH) D3 was positively associated with systolic pressure and diastolic pressure (r =-0.412,-0.377,all P ＜ 0.01),but not significantly associated with the parathyroid hormone,calcium,phosphorous and age.Conclusion There is a high level of hypovitaminosis D in primary hypertension patients.
