CAJ | 학술논문

目的探讨轻中度痤疮患者正常部位皮肤及炎性皮疹部位生理参数的特征.方法 75例轻中度寻常痤疮受试者.每例受试者选择在48 h内出现,直径在2.0～5.0 mm之间的炎性皮疹作为靶皮疹.对靶皮疹及临近靶皮疹的正常部位皮肤进行经表皮失水率、表皮含水量及a*值的检测.洁面后即刻皮脂量、洁面后1 h皮脂量、皮脂饱和值在靶皮疹及双眉之间的额部进行检测并计算皮脂分泌速率.结果随着患者面部炎性丘疹数量的增加,痤疮患者正常部位皮肤的经表皮失水率、皮脂分泌速率显著增高(P<0.05).随着皮疹a*值的增高,皮疹部位经表皮失水率、皮脂分泌速率显著增高(P<0.05).皮疹部位经表皮失水率明显高于正常部位,而皮脂饱和值及皮脂分泌速率均显著低于正常部位(P<0.05).结论痤疮患者炎性丘疹的严重程度与其面部皮肤屏障功能损伤及皮脂分泌速率增高有关.痤疮炎性丘疹部位与正常部位皮肤相比,皮肤屏障功能降低、皮脂分泌速率减小.
목적 탐토경중도좌창환자정상부위피부급염성피진부위생리삼수적특정.방법 75례경중도심상좌창수시자.매례수시자선택재48 h내출현,직경재2.0～5.0 mm지간적염성피진작위파피진.대파피진급림근파피진적정상부위피부진행경표피실수솔、표피함수량급a*치적검측.길면후즉각피지량、길면후1 h피지량、피지포화치재파피진급쌍미지간적액부진행검측병계산피지분비속솔.결과 수착환자면부염성구진수량적증가,좌창환자정상부위피부적경표피실수솔、피지분비속솔현저증고(P<0.05).수착피진a*치적증고,피진부위경표피실수솔、피지분비속솔현저증고(P<0.05).피진부위경표피실수솔명현고우정상부위,이피지포화치급피지분비속솔균현저저우정상부위(P<0.05).결론 좌창환자염성구진적엄중정도여기면부피부병장공능손상급피지분비속솔증고유관.좌창염성구진부위여정상부위피부상비,피부병장공능강저、피지분비속솔감소.
Objective To assess the biophysical characteristics of normal skin and inflammatory skin lesions in mild and moderate acne. Methods Seventy-five mild and moderate acne vulgaris patients were included in the study. One inflammatory lesion measuring 2.0 to 5.0 mm in diameter which occurred within 48 hours prior to the measurement was selected as the target lesion. Trans-epidermis water loss (TEWL), capacitance and a* value were measured in target lesions and lesion-adjacent normal skin. Sebum content immediately,1 and 4 (saturated) hours after face washing was also determined on target lesions and central forehead between the eyebrows. Sebum secretion rate (SSR) was calculated. Results The TEWL and SSR significantly increased in the lesion-adjacent normal skin with the increment of inflammatory lesion number (both P < 0.05), and increased in target lesions with the elevation of a* value (both P < 0.05). The target lesions exhibited a significantly higher TEWL but a lower saturated sebum content and SSR than the adjacent normal skin did (all P <0.05). Conclusions The severity of inflammatory lesions is correlated with the impaired barrier function and increased SSR in facial skin. Compared with the adjacent normal skin, inflammatory skin lesions have a reduced skin barrier function and SSR.