CAJ | 학술논문

目的盐敏感者较早出现靶器官功能损害,其心血管风险增加.本研究探讨血压正常或血压轻度偏高的盐敏感者血管内皮功能改变.方法选99例年龄16～60岁、血压正常或血压轻度偏高者参与为期2周的慢性盐负荷试验,检测盐敏感性.试验包括基线3 d,低盐饮食、高盐饮食各7 d的研究.基线时采用彩色多普勒超声检测血流调节的血管扩张性,反映内皮依耐性血管舒张功能.试验各个阶段测量体重、血压,并收集血、尿标本.结果盐敏感者检出率17.2%,盐敏感与盐不敏感者基线尿钠、钾排泄量无差异,而血浆NO浓度盐敏感者低于盐不敏感者[(61. 2±13.3)μmol/L比(82.5±14.6)μmol/L,P＜0.05];盐敏感者血流介导的肱动脉扩张性低于盐不敏感者[(10.2±2.5)%比(14.5±1.6)%,P＜0.05].结论盐敏感者尽管尚处在血压正常或血压轻度偏高阶段已存在内皮功能损伤.
목적 염민감자교조출현파기관공능손해,기심혈관풍험증가.본연구탐토혈압정상혹혈압경도편고적염민감자혈관내피공능개변.방법 선99례년령16～60세、혈압정상혹혈압경도편고자삼여위기2주적만성염부하시험,검측염민감성.시험포괄기선3 d,저염음식、고염음식각7 d적연구.기선시채용채색다보륵초성검측혈류조절적혈관확장성,반영내피의내성혈관서장공능.시험각개계단측량체중、혈압,병수집혈、뇨표본.결과 염민감자검출솔17.2%,염민감여염불민감자기선뇨납、갑배설량무차이,이혈장NO농도염민감자저우염불민감자[(61. 2±13.3)μmol/L비(82.5±14.6)μmol/L,P＜0.05];염민감자혈류개도적굉동맥확장성저우염불민감자[(10.2±2.5)%비(14.5±1.6)%,P＜0.05].결론 염민감자진관상처재혈압정상혹혈압경도편고계단이존재내피공능손상.
Objective Salt-sensitivity is associated with more severe target organ injury and higher mortality in patients with essential hypertension. We compared the vascular endothelial function between saltsensitive subjects(SS)and non-salt-sensitive subjects(NSS)with normal or mildly increased blood pressure. Methods Ninety-nine subjects(aged 16-60 years)with normal blood pressure or mild hypertension(degree 1)were enrolled. The test program included 3 days baseline investigation, 1 week lowsalt loading phase and 1 week high-salt loading phase. Endothelial function was assessed by measuring the flow mediated dilatation(FMD)of the brachial artery using high resolution ultrasound. Results There was 17. 2% SS. Plasma NOx level[(61.2 ± 13. 3)μmol/L vs(82. 5 ± 14. 6)μmol/L, P ＜ 0. 05]and FMD [(10.2±2.5)%vs(14.5 ± 1.6)%, P ＜0.05]were significantly lower in SS subjects than in NSS subjects. Conclusion Vascular endothelial dysfunction was evidenced in SS subjects with normal blood pressure or in the early stage of hypertension.